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Flashcards in All subjects Deck (109):
1

Thiazide toxicity what increases?

HyperGLUC: glucose, lipid, uric acid, calcium

2

Famiial hyper-cholesterolemia what is wrong

defective or absent LDL receptor

3

Hypertrophic CM what is wrong

beta myosin heavy chain

4

bHCG detection in serum (preg)

day 8 to 11 after ovulation

5

pellagra

niacin def, dementia dermatitis, diarrhea

6

PCA and superior cerebellar A aneurism: nerve involved

III nerve

7

AICA aneurism: nerve involved

facial and vestibulo chochelar nerve

8

Gray baby syndrome

Chloramphenicol

9

Expired tetracycline side effect

Fanconi syndrome

10

Gene involved in fragile X syndrome

FMR1

11

pantothenic acid

vitamin B5, becomes CoA, burning feet syndrome (paresthesia, GIT)

12

ribs and organ injury

spleen 9, 10 and 11; kidney 12

13

phenylketonuria

phenyl alanine hydroxylase or BH4 (musty odor, eczema mental retardation)

14

chronic granulomatous disease

NADPH oxidase (makes superoxide)

15

leukocye adhesion def

type1 (sialyl lewis) and type 2 (CD18 integrin)

16

alkaptonuria

homogentisate oxidase

17

albinism

tyrosinase (DOPA to melanin)

18

branchial cleft cyst

persistent cervical sinus, in the lateral neck

19

increased hat size

pagets disease of the bone

20

squatting releives cyanosis

tetralogy of fallot

21

MOA of potassium citrate in renal stones

bind to ionized calcium and facilitate secretion (citralca)

22

Lesion of damage in Wernicke's encephalopathy

mamillary body, Papez circuit, (B1, Thiamine)

23

SIADH

Both dilutional hyponatremia and euvolemic hyponatremia

24

painless hematuria 2-3 days following URTI

IgA nephropathy

25

which diuretic cause lithium toxicity

thiazide

26

vit E def mimics which disease

Frederick's ataxia

27

3 main causes of metabolic alkalosis

vomiting, diuretics and mineralocorticoid excess

28

ring enhancing lesion

toxoplasmosis

29

fenoldopam is a (& use)

selective D1 agonist (the only drug used in HT emergency which increases renal BF)

30

Nikolsky sign

P. vulgaris

31

Cytochrome P450 enhancers

rifampicin, phenobarbital and phenytoin

32

P450 suppression

cimetidine, amiodarone, sulphonamides

33

SE of lamotrigine

SJS/TEN

34

violent behaviour: substance abuse

PCP (forgets about violent behaviour)

35

drugs for lyme disease

ceftriaxone, doxycycline

36

indication of pulsatile leuprolide

infertility (GnRH analog acts as agonist)

37

prevalence OR is calculated in

cross-sectional study

38

exposure OR is calculated in

case control study

39

HCM murmer increased with

valsalva

40

Anaemia in thalassemia

hypochromic microcytic anemia

41

Granulosa cell tumor secrete

estrogen

42

common drugs for invasive MRSA

Vancomycin, Daptomycin, Linezolid

43

Toxicity and MOA of daptomycin

depolarization of cellular membrane
Myotoxicity

44

Red man syndrome

vancomycin

45

Extra action of propyl thiouracil

Inhibition of T4 to T3 conversion

46

mast cell stabilizers

cromolyn and Nedocromil

47

gastroenteritits transmitted from pet animal

C. jejuni

48

renal agiomyolipoma

tuberous sclerosis (ash leaf pattern on skin)

49

mononuclear leukocytes in diarrhoea

S. typhi

50

prophylactic anti-coagulant for elective hip surgery

heparin

51

SE of colchicine

nausea, abdominal pain and diarrhoea

52

Rx for vWF disease

desmopressin (DDAVP, anti-ADH/vasopressin)

53

you can bend fingers in

OA

54

you can dip sauce in

RA

55

Rheumatoid factor

IgM antibody against Fc of IgG

56

Do MEE

diaphysis
metaphysis
epiphysial carliage (growth plate)
epiphysis

57

Itching after bath

polycythemia vera

58

calcium oxalate crystals in

Ethylene glycol poisoning

59

Two common bugs in SS anemia

pneumococci and H. influenza

60

MOA of entacapone/tolcapone

inhibit COMT and increased L-dopa availability

61

class III antiarrythmic names and properties

Amiodarone
Ibutilide
Dofetilide
Sotalol
AIDS (pottane block)
increase AP, ERP and QT

62

Zidovudine is a (type and special indication)

NRTI

63

absent B cells in peripheral blood

Bruton's agamma globulinemia (BTK defect)

64

Dobutamine MOA and indication

B1 > B2
cardiogenic shock

65

special about Tay-Sachs

No HSM (GM2 ganglioside accumulation)

66

thrombolytics names and MOA

streptokinases and "-plase"s
convert plasminogen to plasmin which cleaves thrombin and fibrin clots

67

antidote for thrombolytics

amino caproic acid

68

seronegative arthritis names

psoriatic
anklylosing spondylitis
IBD
reative
PAIR

69

biliary disease with anti-mitochondrial antibody

primary biliary cirrhosis

70

ECG triad in WPW syndrome

delta wave
short PR interval
wide QRS complex

71

a/c hemolytic transfusion reaction which HS

HS II (ABO incompatibility)

72

criggler najjar syndrome MM

absent UDP glucoronosyl transferase

73

conjugated congential hyperbilirubinema

Dubin-johnsonte Rotor

74

bronchiolitis obliterans

c/c rejection of lung transplants

75

lithium toxicity

LMNOP
movements(tremor)
nephrogenic DI
hypOthyroidism
pregnancy problems

76

psammomma bodies in tumors which ones?

meningioma
papillary ca. of thyroid
serous papillary ovarian adenocarcinoma

77

Rx for CMV retinitis in HIV

Ganciclovir

78

common cause of a/c hemorhagic cystitis

adenovirus

79

tendon commonly involved in rotator cuff syndrome

supraspinatus (empty can test)

80

Drugs metabolized by acetylation

isoniazid, dapsone, hydralazine, procainamide

81

Almost all causes of MS caused by

c/c rheumatic fever

82

hydatid cyst

echinococcus granulosus/multilocularis

83

c/c backpain releived by sitting and bending forward

spinal stenosis

84

lipid lowering drugs that cause gall stones

bile acid resins and fibrates

85

Diphenoxylate

mu receptor opioid for diarhoea (similar to meperidine)

86

3 drugs that inhibit DHFR

trimethoprim, methotrexate, pyrimethamine (malaria and toxoplasmosis)

87

normal pressure hydrocephalus order of symptoms

1st gait and urine, then wacky

88

DOC for PE/venous thrombosis

warfarin

89

familial or essential tremor: clues and Rx

family history (AD), while holding a glass, alcohol releives
Propranolol

90

MENs PPP, PAT and NAT

parathyroid, pancreas, pituitary
Parathyroid, adrenal, thyroid
neuroma, adrenal, thyroid

91

which anesthtic redistribute immediately

barbiturates (thiopental)

92

Rx (and why) for AIP

heme and dextrose (inhibit ALA synthase)

93

difference between strawberry and cherry

strawberry boy
cherry old

94

which AA increased and which is safe in PDH def

alanine increased
Lysine and leucine (purely ketogenic) safe

95

intra-partum penicillin/ampicillin given for

S. agalactae (bacitracin resistant)

96

statin toxicity

hepatotoxicity and myopathy

97

Glitazones MOA (and alternate name)

PPAR gamma (thizolidinedione)

98

hereditary hemorhagic telengectasia aka

Osler-Weber-Rendu
bleeding and telengectasia on skin and mucous membrane

99

Ehler Danlos sydrome

Faulty collagen

100

Rx for Giardia lamblia

Metronidazole

101

Caudal regression syndrome

Uncontrolled DM pregnancy

102

Beck triad: what and seen in

Hypotension, raised JVP, muffled heart sounds
Seen in cardiac tamponade

103

Bartonella henslae causes (3)

cat scratch disease
bacillary angiomatosis
culture negative endocarditis

104

Apple tree atresia/christmas tree deformity

due to obstruction of SM artery

105

behavioral change with ataxia

Huntingtons disease (crazy, went for hunting)

106

spherule filled with endospores

cocciodes immitits

107

Modafinil used for

narcolepsy

108

Thoracocentesis and tube

Both mid axillary line 9 and 6

109

Infundibular PS

Conus arteriosus underdeveloped