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Flashcards in Blood Deck (158):
1

Direct Xa inhibitors

Apixaban Rivaroxaban

2

Direct thrombin inhibitors

Argatroban bivalirudin Dabigatran

3

Methylmalonic acid and A

Increased in B12 def but normal in FA def
Homocysteine increased in both

4

P C tarda enzyme def

Uroporphyrinogen decarboxylase

5

ITP antibody against

GpIIb/IIIa

6

PT and PTT

PT extrinsic(warfarin)
PTT intrinsic (heparin)

7

Skin necrosis of warfarin

protein C/S def

8

waxing and waning lymphadenopathy

follicular lymphoma

9

M. myeloma cf

CRAB (hyperCalcemia, Renal, Anemia, Bone lytic lesions)

10

Waldenstrom macroglobulinemia cf

blurred vision, raynaud phenomenon

11

drug for CML

imatinib (inhibitor of tcr-abl tyrosine kinase)

12

name c/c myeloproliferative disorders

polycythemia vera, essential thrombocytosis, myelofibrosis

13

tear drop RBCs

myelofibrosis

14

mech of heparin

activate anti-thrombin

15

heparin antidote

protamine sulphate

16

DOC for intermittent claudication and mech

Phospho diesterase III inh (cilostazol, dipyridamole)

17

GpIIb/IIIa inhibitors

abciximab, eptifibatide, tirofiban (TEA)

18

Two purine and two pyrimidine anti-metabolites

6MP and cladribine (purine)
cytarabine and 5FU (pyrimidine)

19

Azathioprine is a prodrug

converted to 6MP by HGPRT

20

Vincristine mech, indication, toxicity

bind to beta globulin -> inhibit polymerization of microtubules -> M phase arrest
NHL, neurotoxicity

21

topoisomerase inhibitors for cancers

I (irinotecan and topotecan)
II (etoposide, teniposide)

22

helmet cell (schistocyte) seen in

DIC, TTP/HUS, HELLP, mechanical hemolysis

23

Target cells seen in

HALT the target
HbC disease, Asplenia, Liver disease, Thalassemia

24

names of Hb in a thalassemia

Hb barts 4 alpha
HbH 3 allele disease

25

treatment for sideroblastic anemia

B6

26

what happens to haptoglobin and LDH levels in hemolytic anemia

haptoglobin decrease
LDH increases

27

lead is a ferrocious ally

inhibit ferrochelatase and ALA dehydratase

28

PCT (porphyria cutaneoa tarda) think about

Uro
uroporphyrinogen decarboxylase

29

AIP (a/c intermittent porphyria) is a PORK

porphobilinogen deaminase

30

TdT which leukemia

ALL

31

TRAP which leukemia

HCL

32

ADP receptor inhibitors

PCT
prasugrel, Clopidogrel, Ticlopidine
ticagrelor (reversible)

33

cromolyn sodium MOA

inhibit mast cell degranulation
asthma prophylaxis

34

direct Xa inhibitors

Xabans

35

LMWH greatest efficacy on

Xa

36

direct thrombin inhibitors

argatoban bivalirudin dabigatran

37

streptokinase and alteplase MOA

plasminogen to plasmin

38

Kla kla

clopidogrel, ticlopidine
inhibit ADP receptor
muttathu oru ADP

39

b b b

11b/111a( abciximab,eptifibatide,terofiban

40

big for small and small for big

Bernard soulier syndrome 3 words for Gp1b

41

acanthocyte/spur cell

liver disease and cholesterol problem

42

basophilic stippling

lead poisoning (rRNA)

43

bite cell (degmacyte)

G6PD (bite of fave beans, bite of heinz bodies)

44

sideroblasts iron in

mitochondria

45

schistocytes(helmet cells)

helmet- mechanical injury
DIC

46

schistocyte other word for

helmet cells

47

target cell

HBC,asplenia, liver disease, thalassemia

48

Howell jolly bodies

are joly, not captured by spleen
asplenia

49

opposite of sickling

Heinz bodies (oxidation of SH group)

50

name microcytic anemia

iron,sideroblastic, thalassemia, lead poisoning, ACD

51

third megaloblastic anemia

orotic aciduria

52

name alpha thalassemia

HbBarts and Hb H
remeber Hb pencil/ hemo HB

53

Hb barts chains are

gamma

54

test for beta thal minor

increased HbA2 in electrophoresis

55

B19 aplastic crisis and crew cut

b major and SCA

56

test for beta thal major

increased HbF

57

peripheral neuropathy in lead poisoning

foot drop adn wrist drop

58

lead poisoning treatment

dimercaprol/EDTA
succimer for kids

59

sideroblastic anemia define 2 features

ALA synthase, iron accumulation

60

treatment for sideroblastic anemia

B6

61

2 RBC finding in lead poisoning

basophilic stippling (RNA)
ringed sideroblast (iron in mitochondria)

62

most commom acquired sideroblastic anemia

alcoholism

63

fishworm causes (diphylobothrium latum)

B12 def

64

orotic aciduria vs ornithine transcarbomylase def

only anemia (no hyperammonemia)

65

treatment for orotic acidura

UMP

66

clinical chemistry findings in hemolytic anemia

decreased haptoglobin and increased LDH

67

what is special about ACD

iron low, TIBC low, ferritin high

68

antibiotic causing aplastic anemia

chloramphenicaol

69

most common heriditary cause of aplastic anemia

fanconis anemia

70

heriditary spherocytosis treatment

splenectomy

71

pyruvate kinase def

hemolytic anemia in newborn

72

glutamic acid to lysine

HbC

73

triad of PNH

coombs neg hemolytic anemia, pancytopenia, venous thrombosis

74

treatment of PNH

eculizimab (complement inhibitor)

75

diagnosis of PNH

lack of CD55/59 on RBC

76

autosplenectomy

SCA

77

two treatment for SCA

hydroxyurea
gardos channel blocker (keep RBC hydrated)

78

treatment for AIHA

steroids (cold is miserable)
mycoplasma and IMN

79

pregnancy/OCP effect on iron

TIBC increases (all else normal), increased transferrin

80

lead poisoning accumulated

protoporphyrin and ALA

81

AIP enzyme

porphobilinogen deaminase (porpho adn co porpho accumulate)

82

dont forget - in AIP

psychological disturbance

83

treatment for AIP

heme and glucose(inhibit synthase)

84

PC tarda

uroporphyrinogen decarboxylase

85

hemophilia and time

8,9 11 (only PTT increase)

86

hemophilila treatment

desmopressin (release of vWF and V111

87

ITP which antibody

11b/111a
treatment - steroids and IVIG

88

TTP code

FATTRN

89

cause of TTP

decrease VWF metalloprotease (ADAMTS13)

90

increase fibrin split products

DIC

91

antithrombin def only defect

lack of increase in PTT after heparin

92

factor V leiden vs protein C/S def

thrombosis- skin necrosis after warfarin

93

cryoprecipitate given for

hemophilia A and fibrinogen deficiency

94

leukemoid reaction

Increase LAP

95

viral infecion assoiacted with hodgekins

EBV (bimodal distribution)

96

another name for Doxo

adriamycin (cardio)

97

vinblastine toxicity

myelosuppresion

98

dacarbazine toxicity

azoospermia

99

most common HL

nodular sclerosing (CD 15 and 30)

100

Burk-8 which gene

cMYC (transcription factors)

101

starry sky

burkitt lymphoma

102

most common NHL in adults

diffuse large B cell lymphoma(single large mass)

103

follicular lymphoma which chromosome

BCL 2

104

adult T cell lymphoma caused by

HTLV

105

mycosis fungoides what cells and risk

atypical CD4 with cerebriform nuclei
progress to sezary syndroome
lymphoma to leukemia

106

rouleux formation

MM

107

MM amyloidosis

Primary AL

108

CRAB findings

hypercalcemia, renal failure, anemia, bone lytic lesion/back pain

109

CRAB absent in

waldenstrom and MGUS

110

pseudo pelfer huet

bilobed neutrophils after chemo

111

MDS clinically and risk

CML, can progress to AML

112

ALL 2 types

T cell- mediastinal mass, SVC syndrome
B cell- BM failure

113

Marker for ALL

tdt for both, CD 10 B cell only

114

ALL good prognosis

12:21

115

another name for CLL

SLL

116

TRAP the hairy animal, treatment

cadribine, pentostatin

117

AML M3 feature adn treatment

peroxidase +ve auer rods and all trans retinoic acid, C 15:17

118

AML vs CML

>20%blast,

119

imatinib

bcl-abl tyrosine kinase inhibitor

120

unusual feature of CML

basophilia

121

recurrent otitis media mass involving bone, lytic bone lesion skull

langerhans cell histiocytosis )+ve for s-100 and CD1a

122

name myeloproliferative disorders

polycythemia vera, essential thrombocytosis, myelofibrosis, CML

123

Hot shower and erythromeralgia

polycythemia vera (all cells)

124

essential thrombocytosis

only platelets

125

RBC,WBC, platelets in CML

RBC decreased adn others increased

126

polycythemia classification

priamry- polycythemia vera (decreased EPO)
secondary- appropriate and inappropriate
reactive- blood loss

127

times, warfarin, heparin

warfarin- PT
heparin- PTT and platelet count

128

HIT mechanism

IgG against heparin PF4

129

alternative to heparin

argatoban, bivalirudin, dabigatran

130

thrombolytics complication and antidote

bleeding, aminocaproic acid

131

COX-1 irreversible

aspirin

132

SE of aspirin

tinnitus

133

alternative to aspirin allergy

clopidogrel

134

phosphodiesterase 111 inhibitors and MOA

alostazol, dipyridamole
Increase cAMP, vasodilatation

135

indication of dipyridimaole

intermittent claudication

136

cytarabine SE

pancytopenia

137

MTX 2 supplements

leucovorin for myelosuppression
folic acid for mucositis

138

MTX CI

pregnancy

139

leucovorin is

THF

140

childhood tumors

actinomycin D

141

doxorubicin prevention and SE

dexrazoxane

142

cyclophosphamide and mustines are activated in

liver

143

alkylating agent that cross CNS

mustines

144

tumor lysis syndrome treatment

allopurinol

145

vincristine and blastine toxicity

cristine- neuro
blastine- marrow

146

cisplatin MOA and SE

cross links DNA, nephro adn ototoxci

147

cisplatin SE prevention

amifostine and saline diuresis

148

SE of topoisomerase inhibitors

diarrhea

149

SCA drug

hydroxyurea (increase HbF)

150

Imatinib

Bcr-abl

151

erlotinib

EGFR tyrosine kinase

152

SERM

tamixifen,raloxifene

153

bortezomib

proteosome inhibitor (multiple M)

154

trastuzumab (herceptin) and SE

HER-2, C erbB2/cardiotoxin

155

vemurafenib

BRAF oncogene, melanoma

156

pure red cell aplasia causes

Thymoma, B19

157

tumor lysis syndrome k and Ca

K high, low Ca

158

LDH level in transudate

low