Aminoglycosides

Question 1

Examples:

Answer 1

1. Gentamicin
2. Amikacin
3. Tobramycin
4. Neomycin

Question 2

MOA:

Answer 2

1. Binding to the ribosome
2. Interfering with bacterial protein synthesis

Question 3

Spectrum:

Answer 3

1. Aerobic gram-negative rods - E. coli, Klebsiella, Pseudomonas
2. NOT active against gram-positive cocci unless combined with cell wall agent

Question 4

Indications:

Answer 4

1. MDR infections in critically ill patients
2. VAP
3. Endocarditis - when combined with cell wall agent
4. Zoonotic infections - tularemia, brucellosis

Question 5

S/E:

Answer 5

1. Nephrotoxicity
2. Ototoxicity
3. Neuromuscular blockade - makes postoperative transition from mechanical ventilation difficult