Macrolides

Question 1

Examples:

ACE

Answer 1

1. Azithromycin
2. Clarithromycin
3. Erythromycin

Question 2

MOA:

Answer 2

1. Interferes with bacterial protein synthesis

Question 3

Spectrum:

Answer 3

1. Gram-positive bacteria
2. Gram-negative bacteria (NOT enteric rods or Pseudomonas)
3. Chlamydia / Chlamydophila
4. Mycoplasma
5. Mycobacterium
6. Intracellular bacteria - Legionella
7. Rickettsiae
8. Treponema

Question 4

Indications:

Answer 4

1. URTIs & LRTIs
2. Chlamydial STIs
3. Non-tuberculous mycobacterial infections
4. H. pylori infections

Question 5

S/E:

Answer 5

1. Prolonged QT interval - when combined with antiarrhythmics
2. Transient tinnitus or deafness - erythromycin
3. Worsens Sx of MG - azithromycin