Terbinafine

Question 1

Routes of application:

Answer 1

1. Oral
2. Gel
3. Cream

Question 2

MOA:

Answer 2

1. Squalene peroxidase inhibitor
2. Inhibits conversion of squalene to lanosterol
3. Prevents formation of normal fungal membrane sterol ergosterol

Question 3

Spectrum:

Answer 3

Fungi

Question 4

Indications:

Answer 4

1. Superficial fungal infections due to dermatophytes & candida - fingernails, toenails, tinea corporis, tenia pedis

Question 5

S/E:

Answer 5

1. Abnormal sense of taste & smell
2. Hepatotoxicity
3. Bone marrow suppression
4. Depression
5. SJS

Question 6

Stewardship:

Answer 6

1. NOT be used in underlying liver disease