First Generation Cephalosporins

Question 1

Example:

Answer 1

1. Cefazolin

Question 2

MOA (of ALL Cephalosporins):

Answer 2

1. Interfere with the cell wall
2. Bacterial cell to take on water
3. Burst

Question 3

Spectrum:

Answer 3

1. Gram-positive cocci - Streptococcus
2. Gram-negative rods
3. Activity against Staphylococcus aureus
4. NO activity against MRSA, Enterococcus or Pseudomonas

Question 4

Indications:

Answer 4

1. Skin and soft tissue infections
2. Bacterial pneumonias
3. UTIs