Penicillins

Question 1

Examples:

Answer 1

1. Penicillin G
2. Penicillin V
3. Benzathine penicillin G
4. Aminopenicillins - amoxicillin, ampicillin

Question 2

MOA:

Answer 2

1. Disrupts bacterial cell wall
2. Takes on water
3. Burst

Question 3

Spectrum:

Answer 3

1. Most gram-positive bacteria - Streptococcus, Actinomyces
2. Some gram-negative bacteria - Neisseria meningitidis
3. NO activity against Staphylococcus aureus
4. Aminopenicillins - better activity against gram-negative enteric rods (E.coli) than penicillin G

Question 4

Indications:

Answer 4

1. Pharyngitis/tonsillitis
2. Pneumonia d/t penicillin-susceptible strains of Streptococcus pneumoniae
3. Prevention of rheumatic fever caused by Streptococcus pyogenes (group A strep)
4. Prevention of rheumatic fever recurrence - penicillin V
5. Streptococcal endocarditis
6. Cellulitis
7. Pneumococcal and meningococcal meningitis
8. Syphilis - all stages- benzathine penicillin G
9. Puerperal infections due to anaerobic streptococci or Streptococcus agalactiae (group B strep)
10. Genital clostridial infections
11. Cystitis - amoxicillin
12. Early- and late-stage Lyme disease - amoxicillin

Question 5

S/E:

Answer 5

1. IgE-mediated anaphylaxis
2. Morbilliform rash
3. Diarrhea