Rifamycins

Question 1

Examples:

Answer 1

1. Rifampin
2. Rifabutin
3. Rifaximin

Question 2

MOA:

Answer 2

1. Block the interaction of DNA with RNA polymerase
2. Inhibiting nucleic acid replication

Question 3

Spectrum:

Answer 3

1. Aerobic and anaerobic gram-positive cocci and rods

Question 4

Indications:

Answer 4

1. TB - rifampin
2. Prosthetic valve endocarditis - rifampin
3. Disseminated Mycobacterium avium complex infections in patients with advanced AIDS - rifabutin
4. Traveller’s diarrhea - rifaximin
5. Hepatic encephalopathy - rifaximin

Question 5

S/E:

Answer 5

1. Discoloration of body fluids
2. Flu-like symptoms
3. Hepatotoxicity
4. Drug-drug interactions - increase metabolism of some drugs - Warfarin