Linezolid and Tedizolid

Question 1

MOA:

Answer 1

1. Ribosomal protein inhibitors
2. Bind to the ribosome
3. Prevent the initiation of protein synthesis

Question 2

Spectrum:

Answer 2

1. Gram-positive organisms - including MRSA and VRE

Question 3

Indications:

Answer 3

1. Infections caused by resistant gram-positive organisms
2. Skin and soft tissue infections
3. CAP or HAP - with or
   without bacteremia

Question 4

S/E:

Answer 4

1. Bone marrow suppression / thrombocytopenia
2. Peripheral neuropathy
3. Optic neuropathy
4. Lactic acidosis