Carbapenems

Question 1

MOA:

Answer 1

1. Interferes with cell wall
2. Takes on water
3. Bursts

Question 2

Examples:

Answer 2

1. Imipenem
2. Meropenem
3. Ertapenem
4. Doripenem

Question 3

Spectrum:

Answer 3

1. Gram-positive bacteria - Streptococcus, Staphylococcus
2. NO activity against MRSA
3. Aerobic gram-negative rods - including Pseudomonas (not etrapenem)
4. Most anaerobes

Question 4

Indications:

Answer 4

1. Hospital-acquired infections - VAP and UTIs
2. Mixed infections - wound and intra-abdominal infections