M2 Protein Inhibitors

Question 1

Examples:

Answer 1

1. Amantadine
2. Rimantadine

Question 2

MOA:

Answer 2

1. Interfere with function of viral M2 protein channel
2. Prevents viral replication

Question 3

Spectrum:

Answer 3

1. Respiratory viruses - influenza
2. Now much resistance

Question 4

Indications:

Answer 4

1. Prevention of influenza

Question 5

S/E:

Answer 5

1. CNS toxicity - nervousness, anxiety, confusion, delirium, hallucinations

Question 6

Stewardship:

Answer 6

1. Unlikely to be effective after 48 hours