Analgesia Flashcards Preview

RUSVM Pharmacology 2016 > Analgesia > Flashcards

Flashcards in Analgesia Deck (21):
1

Lidocaine- receptors and use?

Large animal local and systemic anesthetic used to control ventricular arrhythmias, adjunctive analgesia, GI prokinetic, and anti inflammatory

2

Bupivacaine - use and cautions?

Large animal local anesthetic - MOST CARDIOTOXIC

3

Mepivacaine- use?

Diagnostic nerve block in horses

4

Procaine - cautions

Toxic- can cause CNS stimulation - DONT GIVE IV!!

5

Proparacaine- use?

Topical ophthalmic that allows for corneal and conjunctival manipulation

6

NSAIDs - receptors and use?

Inhibit cyclooxygenase enzymes for anti inflammatory, analgesic, antipyretic effects, anti thrombotic effects, and anti neoplastic effects

7

COX-1

Production of prostaglandins that play an important role in normal homeostasis

8

COX-2

Inducible prostaglandins produced during inflammation

9

COX-1 selective inhibitors

Acetylcalicylic acid

10

non specific COX inhibitors

Flunixin
phenylbutazone
ketoprofen

11

COX-2 preferential inhibitors

Deracoxib
Carprofen
Meloxicam

12

COX-2 selective inhibitors

Firocoxib
Robenacoxib

13

Flunixin Meglumine "Banamine" - use?

Soft tissue disease in horses and CATTLE

ONLY NSAID labeled in cattle
DO NOT use in small animal

14

Phenylbutazone "Bute" - use?

Used for musculoskeletal pain in horses

NOT LABELED IN CATTLE!

15

Carprofen, Meloxicam, Deracoxib - receptors and use?

COX-2 preferential for use in small animals as analgesic and anti inflammatory

16

Firocoxib and Robenacoxib - use?

Firocoxib- paste in horses and chewable in dogs
Robenacoxib - ONLY product labeled for multiple IV doses in cats

17

Tramadol - receptors and use?

Weak mu agonist and serotonin and norepinephrine reuptake inhibitor, M1 antagonist - used an an oral analgesia

AVOID IN EPILEPTIC PATIENTS!!

18

Gabapentin- receptors and use?

Alters the calcium influx in neuronal cells - used for the control of neuropathic pain

19

Amantadine - receptors and use?

NMDA antagonist - used as a adjunctive analgesic in small animals

20

Other anti inflammatory & chondroprotective drugs:

Glucosamine chondroitin
Polysulfated gylcoaminoglycans
pentosan polysulfate
Omega 3 fatty acids

21

Local anesthetics - mechanism of actions and use?

Block the propagation of an action potential by inhibiting the flux of sodium through voltage-dependent sodium channels used for minor procedures, lameness localization, pre-and post analgesia for surgery, operative analgesia, and the treatment of ventricular arrhythmias