Immunosuppression and Chemo Flashcards Preview

RUSVM Pharmacology 2016 > Immunosuppression and Chemo > Flashcards

Flashcards in Immunosuppression and Chemo Deck (10):
1

Cyclophosphamide - use?

Immune mediated hemolytic anemia

2

Chlorambucil - use?

Inflammatory bowel disease

3

Cystosine arabinoside - use?

Granulomatous meningoencephalitis

4

Antimetabolites

Impair nuclear synthesis in a rapidly dividing immune cells and block signaling on T cells
Azathioprine
Mycophenoalate mofetil
Leflunomide

5

Azathiprine- use?

Immunosuppression

6

Mycophenolate mofetil - use?

Immune disease unresponsive to other therapies

7

T cell inhibitors

Cyclosporine
Tacrolimus topical

8

Cyclosporine - receptors and use?

Block cyclophillin/calcineurin which reduces T cell activation & response, inhibits production of various cytokines - used to treat keratoconjunctivitis sicca and perianal fistulas

9

Tacrolimus topical - receptors and use?

Same as cyclosporine - used to treat dermatologic disease and perianal fistulas

10

Chemotherapy drugs

Cyclophosphamide
Chlorambucil
Cytosine arabinoside