Sympathomimetics Flashcards Preview

RUSVM Pharmacology 2016 > Sympathomimetics > Flashcards

Flashcards in Sympathomimetics Deck (17):
1

Epinephrine - receptor and Uses?

Alpha-1, Alpha 2, Beta-1, beta-2 agonist – used in cardiac arrest, anaphylaxis, local vasoconstriction and topically for local hemorrhage

2

Norepinephrine- receptor and uses?

Agonist alpha-1 Alpha-2 and beta-1 – causes vasoconstriction and increased afterload

3

Dopamine – receptor and uses?

In low dose Dopamine agonist that causes vasodilation, medium low doses beta-1 agonist causes positive inotrope, medium high dose Beta-1 agonist causes increased heart rate and high-dose beta-1 agonist causes vasoconstriction

4

Dobutamine- receptor and uses?

Same as dopamine – synthetic Beta-1 agonist with minor beta-2 and alpha-1 agonist causes the same effects as dopamine. Used more in large animals especially for acute heart failure

5

Isoproterenol- receptor and uses?

Nonspecific beta agonist causes positive inotropic effect and increased blood flow and bronchodilation – not used in veterinary medicine because of the strong

6

Phenylephrine - receptor and uses?

Direct acting alpha-1 agonist causing increased peripheral vascular resistance used to treat hypertension and cats and dogs

7

Selective beta-2 agonists

Albuterol, salbutamol, clenbuterol, terbutaline, isoxsuprine

8

Albuterol/ Salbutamol- receptor and uses?

Used in inhalers

9

Clenbuterol- receptor and uses?

Used for equine dystocia because it causes uterine relaxation

10

Terbutaline -receptor and uses?

Used in small animal for bronchodilation

11

Isoxsuprine -receptor and uses?

Used for bovine dystocia

12

Nonselective beta agonist Ractopamine and Zilpaterol -receptor and uses?

Beta 3 agonist used for increased carcass leanness, feed efficiency, and increased deposition of muscle

13

Indirect acting sympathomimetics

Clomipramine- serotonin agonist
Doxepin- serotonin agonist- antihistamine
Monoamine oxidase inhibitor- Selegiline- inhibits the reuptake of norepinephrine and breakdown

14

Direct and indirect acting sympathomimetics

Phenylpropanolamine
Ephedrine

15

Phenylpropanolamine -receptor and uses?

Direct alpha-1 agonist used to treat urinary incontinence due to urethral sphincter are incompetence

16

Ephedrine -receptor and uses?

Direct alpha-1 and beta agonist used as a CRO to maintain blood pressure under anesthesia causes increased blood pressure, cardiac stimulation and bronchodilation

17

Direct Acting Catecholamines

Epinephrine
norepinephrine
dopamine
dobutamine
isoproterenol
Phenylephrine