Autocoids Flashcards Preview

RUSVM Pharmacology 2016 > Autocoids > Flashcards

Flashcards in Autocoids Deck (20):
1

H1 antagonist first-generation effects

Cross the blood brain barrier and have CNS depressant effects and anti-cholinergic effects

2

H1 antagonist second generation effects

Poor penetration of the blood brain barrier and exhibit noncompetitive/competitive antagonists

3

H 1 antagonist first generation and second-generation- receptor and uses?

Used for a local allergies, anaphylaxis, anti-motion sickness (anti emetics)

4

H2 antagonists

Cimetidine
Ranitidine
Famotidine
nizatidine

5

H2 antagonists- receptor and uses?

Competitive antagonist to H2 receptors - used for peptic ulcers, gastric erosive disease, gastric esophageal reflux disease, and duodenal ulcer

6

Cimetidine - receptor and uses?

Competitive H2 antagonist- used in equine melanoma

7

Ranitidine and Nizatidine - receptor and uses?

Competitive H2 antagonist- used as a prokinetic

8

Serotonin agonists

Cisapride
Fluoxetine

9

Cispride - receptor and uses?

Serotonin 4 receptor agonist used for prokinetic in colic and impaction

10

Fluoxetine - receptor and uses?

Selective serotonin reuptake inhibitor used as an antidepressant in the treatment of canine anxiety and for treatment of cats with inappropriate elimination or marking

11

Neurokinin antagonists

Miropitant Citrate (Cerenia)

12

Miropitant Citrate (Cerenia) - receptor and uses?

Blocks neurokinin 1 receptors used for the prevention of a acute vomiting due to motion sickness, viral infections, anticancer drugs

13

Prostaglandin inhibitors

Cyclooxygenase inhibitors: NSAIDs
phospholipase A2 inhibitors: corticosteroids

14

Janus kinase inhibitor- receptor and uses?

Inhibits pruritogenic and proinflammatory cytokines - used in the control of periodic allergic dermatitis and atopic dermatitis

15

Serotonin Antagonists

Cyproheptadine
Ondensetron
Metaclopramide
Mirtazapine

16

Cyproheptadine- receptor and uses?

Blocks H1 receptors and serotonin receptors - used as an antihistamine, stimulates appetite, and for the treatment of serotonin syndrome in dogs and cats

17

Ondansetron- receptor and uses?

Inhibits serotonin receptor - used for the prevention and treatment of anti-cancer nausea and vomiting

18

Metoclopramide - receptor and uses?

Serotonin 3 receptor antagonist and dopamine 1&2 antagonist - used as an antiemetic and prokinetic

19

Mirtazapine - receptor and uses?

serotonin 2 & 3 receptor antagonist - used as an antidepressant( tricyclic antidepressant) and antiemetic

20

Antihistamines

Drugs that competitively block histamine receptors H1 or H2