Flashcards in Autocoids Deck (20):
H1 antagonist first-generation effects
Cross the blood brain barrier and have CNS depressant effects and anti-cholinergic effects
H1 antagonist second generation effects
Poor penetration of the blood brain barrier and exhibit noncompetitive/competitive antagonists
H 1 antagonist first generation and second-generation- receptor and uses?
Used for a local allergies, anaphylaxis, anti-motion sickness (anti emetics)
H2 antagonists- receptor and uses?
Competitive antagonist to H2 receptors - used for peptic ulcers, gastric erosive disease, gastric esophageal reflux disease, and duodenal ulcer
Cimetidine - receptor and uses?
Competitive H2 antagonist- used in equine melanoma
Ranitidine and Nizatidine - receptor and uses?
Competitive H2 antagonist- used as a prokinetic
Cispride - receptor and uses?
Serotonin 4 receptor agonist used for prokinetic in colic and impaction
Fluoxetine - receptor and uses?
Selective serotonin reuptake inhibitor used as an antidepressant in the treatment of canine anxiety and for treatment of cats with inappropriate elimination or marking
Miropitant Citrate (Cerenia)
Miropitant Citrate (Cerenia) - receptor and uses?
Blocks neurokinin 1 receptors used for the prevention of a acute vomiting due to motion sickness, viral infections, anticancer drugs
Cyclooxygenase inhibitors: NSAIDs
phospholipase A2 inhibitors: corticosteroids
Janus kinase inhibitor- receptor and uses?
Inhibits pruritogenic and proinflammatory cytokines - used in the control of periodic allergic dermatitis and atopic dermatitis
Cyproheptadine- receptor and uses?
Blocks H1 receptors and serotonin receptors - used as an antihistamine, stimulates appetite, and for the treatment of serotonin syndrome in dogs and cats
Ondansetron- receptor and uses?
Inhibits serotonin receptor - used for the prevention and treatment of anti-cancer nausea and vomiting
Metoclopramide - receptor and uses?
Serotonin 3 receptor antagonist and dopamine 1&2 antagonist - used as an antiemetic and prokinetic
Mirtazapine - receptor and uses?
serotonin 2 & 3 receptor antagonist - used as an antidepressant( tricyclic antidepressant) and antiemetic