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RUSVM Pharmacology 2016 > GI Drugs > Flashcards

Flashcards in GI Drugs Deck (21):
1

Peripherally acting emetics

Hydrogen peroxide

2

Hydrogen peroxide

Direct irritation of oropharynx - for immediate treatment at home

do not use in cats!!

3

Centrally acting emetics

Apomorphine
Xylazine
Dexmedetomidine

4

Apomorphine - receptors and uses?

Stimulates dopamine receptors - centrally acting emetic in dogs

5

Xylazine and Dexmedetomadine - receptors and use?

Alpha -2 agonists - centrally acting emetic

6

Maropitant - receptor and uses?

Neurokinin 1 receptor antagonist - prevention of motion sickness and dogs and treatment of acute vomiting in dogs and cats

7

Metoclopramide- receptor and use?

Dopamine antagonist - antiemetic

8

Ondansetron - receptor and uses?

Serotonin antagonist - anticancer drug antiemetic

9

Antiulcer medications

H2 blockers
Proton pump inhibitors
Oral antacids
Prostaglandin analogs
Gastroprotectants

10

H2 blockers

Cimetidine
Ranitidine
Famotidine

11

H2 blockers - receptor and uses?

Block H2 receptors for inhibition of gastric acid and pepsin secretion

12

Cimetidine - Fun Fact!

Inhibitor of hepatic microsomal enzymes

13

Omeprazole - receptor and uses?

Inhibits proton pump resulting in decreased hydrochloric acid production to raise gastric pH

14

Oral antacids - receptor and uses?

Inactivates Pepsin and binds to bile salts and stimulates prostaglandins, binds to phosphorus - used to chemically neutralize HCl

15

Prostaglandin analogs

Misoprostol

16

Misoprostol - receptor and uses?

Increases mucus and sodium bicarbonate secretion, stimulates epithelialization of the mucus and mucosal blood flow- treats NSAID induced gastric ulcers

17

Sucralfulate

A sucrose aluminum compound that binds to the ulcer site and stimulates protective prostaglandins and antioxidants and increase mucosal blood flow - used to protect against acid, pepsin and bile

will inhibit the absorption of other drugs!!

18

Drugs that induce gastric motility

Dopamine antagonists: metoclopromide &domperidone
Serotonin agonists- cisapride &mosapride
Ranitidine
Erythromycin
Lidocaine
Cholinergics

19

Drugs that decrease gastric motility

Anticholinergics: Aminopentamide & atropine/glycopyrrolate
Opioids: loperamide
GI protectants and adsorbents

20

GI protectants and adsorbents

Magnesium/aluminum products
Bismuth subsalicylate
Activated charcoal

21

Stimulants of appetite

Norepinephrine (alpha -2)
Dopamine
GABA agonists