Anti-epileptic Flashcards Preview

RUSVM Pharmacology 2016 > Anti-epileptic > Flashcards

Flashcards in Anti-epileptic Deck (14):
1

Epilepsy

Seizures that occurs intermittently over months to years for which the underlying cause cannot be identified

2

Status epilepticus

Repeated seizures without full recovery between them or a single seizure that last greater than five minutes

3

Cluster seizures

More than one seizure occurring within a 24 hour period With recovery in between

4

Anticonvulsants

Drugs that prevent or treat seizures

5

Antiepileptic drugs

Generally refers to maintenance management of epileptic seizures

6

Diazepam - cautions?

Binds to the plastic in the syringes

DO NOT store in a syringe!!

7

Phenobarbital -receptor and use?

Potential GABA receptor activity used as a first-line drug in both dogs and cats - Antiepileptic drug

8

Phenobarbital - cautions?

Can cause polyuria, polydipsia, polyphagia, elevated liver enzyme, hepatotoxicity, and decreases T4 mimicking hypothyroidism

9

Antiepileptic drugs

Phenobarbital
Bromide
Levetiracetam
Zonisamide
Imepitoin

10

Bromide - receptor and use?

Competing with the chloride transport across cell membranes -used as a primary and epileptic or Add on

Do not use in cats! watch for "Bromism" toxicity!

11

Levetiracetam - receptor and use?

Binds to presynaptic vesicles to alter the release of neurotransmitters to inhibit seizure generation or propagation - used as a primary antiepileptic or add on to others
not suitable for animals with liver disease!

12

Zonisamide- receptor and use?

Block sodium channel to stabilize neurons preventing hyper synchronization- used most commonly as an add-on and first line anti-epileptic

13

Imepitoin - receptor and use?

Partial agonist at benzodiazepine binding sites on GABA receptors - function similar to diazepam and full benzodiazepine agonists

14

Seizure

Clinical manifestation of abnormal electrical activity in the brain