Anti-epileptic Flashcards
(14 cards)
Epilepsy
Seizures that occurs intermittently over months to years for which the underlying cause cannot be identified
Status epilepticus
Repeated seizures without full recovery between them or a single seizure that last greater than five minutes
Cluster seizures
More than one seizure occurring within a 24 hour period With recovery in between
Anticonvulsants
Drugs that prevent or treat seizures
Antiepileptic drugs
Generally refers to maintenance management of epileptic seizures
Diazepam - cautions?
Binds to the plastic in the syringes
DO NOT store in a syringe!!
Phenobarbital -receptor and use?
Potential GABA receptor activity used as a first-line drug in both dogs and cats - Antiepileptic drug
Phenobarbital - cautions?
Can cause polyuria, polydipsia, polyphagia, elevated liver enzyme, hepatotoxicity, and decreases T4 mimicking hypothyroidism
Antiepileptic drugs
Phenobarbital Bromide Levetiracetam Zonisamide Imepitoin
Bromide - receptor and use?
Competing with the chloride transport across cell membranes -used as a primary and epileptic or Add on
Do not use in cats! watch for “Bromism” toxicity!
Levetiracetam - receptor and use?
Binds to presynaptic vesicles to alter the release of neurotransmitters to inhibit seizure generation or propagation - used as a primary antiepileptic or add on to others
not suitable for animals with liver disease!
Zonisamide- receptor and use?
Block sodium channel to stabilize neurons preventing hyper synchronization- used most commonly as an add-on and first line anti-epileptic
Imepitoin - receptor and use?
Partial agonist at benzodiazepine binding sites on GABA receptors - function similar to diazepam and full benzodiazepine agonists
Seizure
Clinical manifestation of abnormal electrical activity in the brain
