ANP, Renal Prostaglandins, ADH Flashcards Preview

Urinary Exam 2 > ANP, Renal Prostaglandins, ADH > Flashcards

Flashcards in ANP, Renal Prostaglandins, ADH Deck (49)
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1

What are the three forms of natriuretic peptides?

ANP
BNP
CNP

2

When are the natriuretic peptides released?

Under control of stretch receptors in the right atrium and ventricles

3

What are the potency of natriuretic peptides from greatest to least?

ANP > BNP > CNP

4

Which natriuretic peptides are better vasodilators?

CNP

5

Which natriuretic peptides are more effective natriuretics?

ANP
BNP

6

What cleaves ANP, BNP, CNP in the plasma?

Neprilysin (neutral endopeptidases/metalloprotease)

7

What does ANP C receptor do?

Binds the natriuretic peptides and internalizes them into the cell

8

What does inhibition of neprilysin cause?

Natriuresis

9

What is Sacubitril?

A prodrug converted by esterases to an inhibitor of metalloproteases

10

What are metalloproteases?

Neutral endopeptidases

11

What do neutral endopeptidases do?

Breaksdown endothelin, A2, ANP

12

What does Sacubitril do?

Inhibits neutral endopeptidases/metalloproteases

13

What is Sacubitril used to treat?

In combination with valsartan (A2 antagonist) for CHF

14

What are the three natriuretic peptide receptors?

A B and C

15

What do A and B natriuretic peptide receptors do?

Have physiological actions

16

What does natriuretic C peptide receptor do?

Gets rid of ANP, internalizes receptor with peptide bound to it

17

What is a marker for heart failure/LV dysfunction?

BNP levels (higher levels is worse)

18

Where is BNP released from?

Left ventricle

19

What drug is essentially BNP in a bottle?

Neseritide

20

What is Neseritide used for?

Patients on the maximum amount of diuretic that still need help via natriuresis

21

What is a potential side effect of Neseritide?

Depletion of patients plasma sodium

22

Which endothelin has pathological involvement in pulmonary HTN?

ET-1

23

What causes release of endothelin?

Low shear stress on vascular endothelium

24

Three ET receptors and what each do?

ETa: vascular smooth muscle contraction
ETb: vascular smooth muscle contraction
ETb: endothelium vasodilation via NO and prostacyclin release

25

What is Bosentan?

Non-selective (ETa, ETb, ETc) antagonist

26

What is Ambrisentan?

Selective ETa receptor antagonist

27

When would you give Ambrisentan?

For blocking ETa in pulmonary hypertension

28

Where is vasopressin made?

Supraoptic and paraventricular nuclei

29

Where is vasopressin released from?

Posterior pituitary

30

What triggers release of vasopressin?

In response to changes in plasma hyperosmolality (controlled by drugs too)