Flashcards in ANP, Renal Prostaglandins, ADH Deck (49)
What are the three forms of natriuretic peptides?
When are the natriuretic peptides released?
Under control of stretch receptors in the right atrium and ventricles
What are the potency of natriuretic peptides from greatest to least?
ANP > BNP > CNP
Which natriuretic peptides are better vasodilators?
Which natriuretic peptides are more effective natriuretics?
What cleaves ANP, BNP, CNP in the plasma?
Neprilysin (neutral endopeptidases/metalloprotease)
What does ANP C receptor do?
Binds the natriuretic peptides and internalizes them into the cell
What does inhibition of neprilysin cause?
What is Sacubitril?
A prodrug converted by esterases to an inhibitor of metalloproteases
What are metalloproteases?
What do neutral endopeptidases do?
Breaksdown endothelin, A2, ANP
What does Sacubitril do?
Inhibits neutral endopeptidases/metalloproteases
What is Sacubitril used to treat?
In combination with valsartan (A2 antagonist) for CHF
What are the three natriuretic peptide receptors?
A B and C
What do A and B natriuretic peptide receptors do?
Have physiological actions
What does natriuretic C peptide receptor do?
Gets rid of ANP, internalizes receptor with peptide bound to it
What is a marker for heart failure/LV dysfunction?
BNP levels (higher levels is worse)
Where is BNP released from?
What drug is essentially BNP in a bottle?
What is Neseritide used for?
Patients on the maximum amount of diuretic that still need help via natriuresis
What is a potential side effect of Neseritide?
Depletion of patients plasma sodium
Which endothelin has pathological involvement in pulmonary HTN?
What causes release of endothelin?
Low shear stress on vascular endothelium
Three ET receptors and what each do?
ETa: vascular smooth muscle contraction
ETb: vascular smooth muscle contraction
ETb: endothelium vasodilation via NO and prostacyclin release
What is Bosentan?
Non-selective (ETa, ETb, ETc) antagonist
What is Ambrisentan?
Selective ETa receptor antagonist
When would you give Ambrisentan?
For blocking ETa in pulmonary hypertension
Where is vasopressin made?
Supraoptic and paraventricular nuclei
Where is vasopressin released from?