Human Leukoctye Anitgen and Tissue Typing Flashcards Preview

Urinary Exam 2 > Human Leukoctye Anitgen and Tissue Typing > Flashcards

Flashcards in Human Leukoctye Anitgen and Tissue Typing Deck (14)
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1

Where are MHC I receptors found?

On all nucleated cells

2

Where are MHC II receptors found?

Macrophages
Dendritic cells
B lymphocytes

3

What is the structure of MHC I receptors?

Alpha 1 and 2 chains at distal end
Beta 1 and alpha 3 chains at proximal end

4

What is the structure of MHC II receptors?

Alpha 1 and beta 1 chains at distal end
Alpha 2 and beta 2 chain at proximal end

5

What do MHC I receptors bind to? Why?

CD8+
Alpha 3 is coreceptor

6

What do MHC II receptors bind to? Why?

CD4+
Beta 2 is coreceptor

7

What does it mean that MHC molecules are codominantly expressed?

Alleles from each parent are expressed equally

8

What does a haplotype mean?

That MHC alleles are inherited as a set on each chromosome

9

Three polymorphisms of MHC I:

HLA-A
HLA-B
HLA-C

10

Four polymorphisms of MHC II:

HLA-DP
HLA-DQ
HLA-DR alpha
HLA-DR beta

11

What is critical in solid organ transplants?

Making sure the patient has not made antibodies against the donors antigens

12

What are three components of HLA testing for transplants?

1.) HLA typing of donors and patients
2.) HLA antibody screening of patients
3.) Lymphocyte cross-matching (donor only) after the match is found

13

What are three ways patients can form antibodies against the donor?

1.) Multiple pregnancies from exposure to the fathers HLA
2.) Blood or platelet formation
3.) Previous organ transplants

14

What does lymphocyte cross-matching look for?

Tests to see if the donors lymphocytes have antibodies directed against the patients serum