Flashcards in Human Leukoctye Anitgen and Tissue Typing Deck (14)
Where are MHC I receptors found?
On all nucleated cells
Where are MHC II receptors found?
What is the structure of MHC I receptors?
Alpha 1 and 2 chains at distal end
Beta 1 and alpha 3 chains at proximal end
What is the structure of MHC II receptors?
Alpha 1 and beta 1 chains at distal end
Alpha 2 and beta 2 chain at proximal end
What do MHC I receptors bind to? Why?
Alpha 3 is coreceptor
What do MHC II receptors bind to? Why?
Beta 2 is coreceptor
What does it mean that MHC molecules are codominantly expressed?
Alleles from each parent are expressed equally
What does a haplotype mean?
That MHC alleles are inherited as a set on each chromosome
Three polymorphisms of MHC I:
Four polymorphisms of MHC II:
What is critical in solid organ transplants?
Making sure the patient has not made antibodies against the donors antigens
What are three components of HLA testing for transplants?
1.) HLA typing of donors and patients
2.) HLA antibody screening of patients
3.) Lymphocyte cross-matching (donor only) after the match is found
What are three ways patients can form antibodies against the donor?
1.) Multiple pregnancies from exposure to the fathers HLA
2.) Blood or platelet formation
3.) Previous organ transplants