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Flashcards in Introduction to Renal Pathology II Deck (22)
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1

What is primary glomerular disease?

Intrinsic kidney disease

2

What typically causes primary glomerular disease?

Immune-mediated

3

What is secondary glomerular disease?

Extra-renal systemic disease affecting glomerulus

4

What can cause hematuria only?

Hereditary condition affecting the composition of the GBM

5

What causes nephrotic syndrome?

Increased permeability of GFB

6

What causes nephritic syndrome?

Immune-mediated inflammation

7

What are the clinical features of nephrotic syndrome?

1.) Proteinuria (>3.5g/day)
2.) Hypoalbuminemia
3.) Hyperlipidemia
4.) Edema

8

What are the clinical features of nephritic syndrome?

1.) Proteinuria (

9

Do you do a biopsy in nephritic or nephrotic syndrome?

Nephrotic not nephritic

10

How does nephritic syndrome happen?

Ag-Ab complexes in circulation planted in glomerulus

11

When staining the glomerulus with immunofluorescent staining what are three staining patterns observed?

Lumpy
Linear
Granular

12

What does the immunofluorescent staining pattern tell?

Can elude to which immune complexes are present due to the pattern

13

What is podocytes effacement?

Shortening or thinning of the podocytes feet

14

Four places that Ab-Ag complexes can deposit in the glomerulus?

1.) Subepithelium
2.) Epimembrane
3.) Subendothelium
4.) Mesangial cells

15

What occurs in sclerosis?

EC proteins make it into the capillary wall causing hardening and narrowing

16

What characterizes rapidly progressive glomerulosclerosis?

Rapid proliferation of the parietal epithelial cells ( hypercellularity of cells that make up Bowman's capsule around the glomerulus)

17

What does the proliferation of parietal epithelial cells look like in a LM?

Crescent shape around the glomerulus

18

Where do anionic complexes deposit?

Subendothelium

19

Where do cationic complexes deposit?

Subepithelium

20

Where are complexes deposited for lumpy?

Subendothelium

21

Where are complexes deposited for granular?

Subepithelium

22

Where are complexes deposited for linear?

Endothelium