Flashcards in Immunosuppressants Deck (6)
What are induction drugs?
Powerful antirejection medicine used at the time of transplant
What are maintenance drugs?
Antirejection medications used for long term
Cyclosporine/Tacrolimus mechanism of action:
Block T cell cytokine production by inhibiting the phosphatase caclineurin and thus blocking activation of the NFAT transcription factor
Sirolimus (rapamycin) mechanism of action:
Blocks lymphocyte proliferation by inhibiting mTOR and IL-2 signaling
Monoclonal antibodies specific for interleukin-2 receptor mechanism of action (CD-25 blocker):
Inhibits T cell proliferation by blocking IL-2 binding; may also opsonize and help eliminate activated IL-2R-expressing T cells