Flashcards in Pharmacology of Antiviral Drugs Deck (51)
What are the viral cell attachment inhibitors?
What are the viral Penetration inhibitors?
What are the viral nucleic acid uncoating inhibitors?
What are the 3 groups of transcription inhibitors?
Nucleoside/nucleotide reverse transcriptase inhibitors
Non-nucleotide/nucleoside reverse transcriptase inhibitors
Viral DNA polymerase inhibitors
What are the nucleoside/nucleotide reverse transcriptase inhibitors?
What are the non-nucleoside/nucleotide reverse transcriptase inhibitors?
What are the viral DNA polymerase inhibitors?
What are the protease inhibitors?
What are the viral release inhibitors?
What is Enfuvirtide specific for?
How is Enfuvirtide metabolized?
What is Enfuvirtide saved for?
Salvage therapy in HIV-1
How does Enfuvirtide work?
Inhibits HIV binding to CD4 cells
What is Maraviroc used to treat?
How does Maraviroc work?
Specifically binds host cell cytokine receptor (CCR5) needed for HIV entry into the cell
How is Maraviroc metabolized?
P450 CYP3A4 metabolism and renal excretion
How is Maraviroc transported out of the GI tract?
G glycoprotein substrate
What is Docosanol used to treat?
What type of compound is Docosanol?
A 22 carbon aliphatic alcohol
How does Docosanol work?
Inhibits fusion between plasma membrane and herpes simplex virus envelope preventing viral entrance into the cell
Maraviroc main adverse effects?
Cough, upper respiratory infections, muscle-joint pain
What is Palivizumab used to treat?
Respiratory syncytial virus
How does Palivizumab work?
Monoclonal antibody directed against a surface protein antigen on RSV
Adverse effects of Palivizumab?
Elevated liver transaminases
What is Palivizumab really?
A monoclonal antibody injected prophylactically
What population would you use Palivizumab?
Premature babies and infants at high risk
What are the three chemically different forms of interferons produced by human cells?
What cells produce type I interferons?
What cells produce type II interferons?