Pharmacology of Antiviral Drugs Flashcards Preview

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Flashcards in Pharmacology of Antiviral Drugs Deck (51)
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1

What are the viral cell attachment inhibitors?

Palivizumab
Maraviroc
Enfuvirtide
Docosanol

2

What are the viral Penetration inhibitors?

Interferons

3

What are the viral nucleic acid uncoating inhibitors?

Amantadine
Rimantadine

4

What are the 3 groups of transcription inhibitors?

Nucleoside/nucleotide reverse transcriptase inhibitors
Non-nucleotide/nucleoside reverse transcriptase inhibitors
Viral DNA polymerase inhibitors

5

What are the nucleoside/nucleotide reverse transcriptase inhibitors?

Zidovudine

6

What are the non-nucleoside/nucleotide reverse transcriptase inhibitors?

Efavirenz

7

What are the viral DNA polymerase inhibitors?

Ganciclovir
Acyclovir

8

What are the protease inhibitors?

Saquinavir

9

What are the viral release inhibitors?

Oseltamivir
Zanamivir

10

What is Enfuvirtide specific for?

HIV-1

11

How is Enfuvirtide metabolized?

Proteolytic hydrolysis

12

What is Enfuvirtide saved for?

Salvage therapy in HIV-1

13

How does Enfuvirtide work?

Inhibits HIV binding to CD4 cells

14

What is Maraviroc used to treat?

HIV

15

How does Maraviroc work?

Specifically binds host cell cytokine receptor (CCR5) needed for HIV entry into the cell

16

How is Maraviroc metabolized?

P450 CYP3A4 metabolism and renal excretion

17

How is Maraviroc transported out of the GI tract?

G glycoprotein substrate

18

What is Docosanol used to treat?

Herpes simplex

19

What type of compound is Docosanol?

A 22 carbon aliphatic alcohol

20

How does Docosanol work?

Inhibits fusion between plasma membrane and herpes simplex virus envelope preventing viral entrance into the cell

21

Maraviroc main adverse effects?

Cough, upper respiratory infections, muscle-joint pain

22

What is Palivizumab used to treat?

Respiratory syncytial virus

23

How does Palivizumab work?

Monoclonal antibody directed against a surface protein antigen on RSV

24

Adverse effects of Palivizumab?

Elevated liver transaminases

25

What is Palivizumab really?

A monoclonal antibody injected prophylactically

26

What population would you use Palivizumab?

Premature babies and infants at high risk

27

What are the three chemically different forms of interferons produced by human cells?

Type I
Type II
Interferon receptors

28

What cells produce type I interferons?

Leukocytes
Fibroblasts

29

What cells produce type II interferons?

T cells
NK cells

30

What are type I interferons produced in response to?

Viral stimulation