Flashcards in Introduction to Renal Pathology I Deck (37)
What are the three non-neoplastic kidney diseases?
What labs do you look at for kidney altered function?
What labs do you look at for kidney altered structures?
What are three methods you would use with a tissue biopsy?
What stains do you use for in light microscopy?
H and E
What do you use in immunofluorescence?
Antibodies to identify abnormal proteins in glomerulus; usually inflammation looking for complement
What do you look for with an electronmicroscopy?
Altered ultrastructure, primarily glomerulus
What is found in azotemia?
Increased BUN and creatinine in the serum
What are non-neoplastic renal diseases also called and why?
Medical kidney diseases
Because they do not require surgical intervention just medical intervention
What does Renovascular disease typically have to do with?
What does Tubulointerstitial disease involve and what causes it?
Tubular ducts or interstitium damage caused by toxins, ischemia or drugs
What usually causes glomerular disease?
What altered function comes from glomerulus disease?
Issue with filtration and decreased GFR
What altered function comes from tubule disease?
Reabsorption and secretion
What are the clinical manifestations of azotemia?
Increased BUN and creatinine plasma levels due to decreased GFR
What is seen in nephritic (inflammation of) syndrome?
Mild to moderate proteinuria
What is seen in nephrotic (disease of) syndrome?
Altered glomerular filtration barrier
What is severe edema due to loss of protein called?
What does azotemia lead to?
Uremia and multisystem organ failure
What characterizes acute kidney injury?
Rapid decrease in GFR
Increase in BUN/Cr
Oliguria or anuria
What characterizes chronic kidney disease?
Persistent decrease in GFR
What characterizes end-stage renal disease?
GFR less than 5% normal
What characterizes renal tubular defects?
What is nephrolithiasis?
Kidney stone formation IN the kidney
What is urolithiasis?
Kidney stone formation somewhere (other than kidney) in the urinary tract
What are the barriers the filtrates must cross from inside the BV to the tubule?
Capillary endothelial cells
Glomerular basement membrane
Visceral epithelial cells (podocytes)
What are the parietal epithelial cells?
Cells that make up the tubules
What are mesangial cells?
Cells embed in the GBM and ECM
Role of mesangial cells?
Creation of EC proteins