ANS pt 2 - slides 18+

Question 1

what explains some of the adverse effects associated with non-selective beta blockers

Answer 1

unwanted blockade of beta 2 receptors instead of the targeted beta 1

Question 2

what are two mixed-acting sympathomimetics that can be used to treat nasal congestion

Answer 2

ephedrine
pseudoephedrine

Question 3

name an alpha 2 antagonist

Answer 3

yohimbine

Question 4

what are beta 1 antagonists used to treat

Answer 4

hypertension
angina
arrhythmias

Question 5

what is the action of alpha 1 antagonists

Answer 5

reduces vasoconstriction and peripheral resistance

Question 6

name 4 uses of alpha 1 agonists

Answer 6

control superficial bleeding
reduces congestion
mydirasis
hypotensive emergencies

Question 7

how do you treat toxicity of amphetamine

Answer 7

acidification of urine

Question 8

what is a use of clonidine (alpha 2 agonist)

Answer 8

antihypertensive

Question 9

what are the 3 kinds of indirect acting sympathomimetics

Answer 9

displacement drugs

inhibit reuptake of NE from synapse

Inhibit NE breakdown in neurons

Question 10

adverse effects of beta 1 blockade

Answer 10

bradycardia
HF
hypotension

Question 11

what are some adverse effects of amphetamine

Answer 11

insomina
irritability
psychosis
anorexia
tacchycardia
dependance
tolerance

Question 12

name 7 uses for beta antagonists

Answer 12

angina
hypertension
HF
post MI
arrhythmias
stage fright/anxiety
migrane prophylaxis

Question 13

what is the mechanism of adrenergic antagonists

Answer 13

generally reversible blockade of adrenergic receptors

Question 14

what is an adverse effect of alpha 1 agonists

Answer 14

excessive inc in BP

Question 15

what is a reversible non-selective alpha antagonist

Answer 15

phentolamine

Question 16

what receptors can dopamine bind to

Answer 16

Dopamine receptors
alpha 1
beta 1
beta 2

Question 17

what type of drug is propranolol

Answer 17

non-selective beta antagonist

Question 18

what is the use of mirabegron

Answer 18

reduce urinary urgency/incontinence

Question 19

what are 3 uses of amphetamine

Answer 19

stimulates CNS
treat ADD
decrease appetite

Question 20

what kind of drug is yohimbine

Answer 20

alpha 2 antagonist

Question 21

what receptors can adrenaline bind to

Answer 21

alpha and beta adrenergic receptors

Question 22

what’s a example of a beta 1 agonist

Answer 22

dobutamine

Question 23

name an alpha 1 agonist

Answer 23

phenylephrine

Question 24

what is a use for dobutamine (beta 1 agonist)

Answer 24

treat acute heart failure

Question 25

what is the effect of salbutamol

Answer 25

dilates bronchi

Question 26

how do displacement drugs work

Answer 26

stimulate release of stored NA from vesicles into the synapse

Question 27

what is the use of alpha 1 antagonists

Answer 27

treats hypertension

Question 28

adverse effects of beta 2 blockage

Answer 28

bronchoconstriction inhibition of hepatic glycogenolysis inhibition of hypoglycemia symptoms inhibiton of lipolysis inhibition of peripheral vasodilation of BVs

Question 29

what receptors can noradrenaline bind to

Answer 29

alpha 1,2 beta 1

Question 30

name 3 alpha 1 antagonists

Answer 30

prazosin terazosin doxazosin

Question 31

what is the name for the NE-secreting tumour

Answer 31

pheochromocytoma

Question 32

what is isoproterenol

Answer 32

non selective adrenergic agonist

Question 33

what is the effect of dobutamine

Answer 33

inc HR inc force of contraction

Question 34

what is a example of a alpha 2 agonist

Answer 34

clonidine

Question 35

what are 3 adverse effects of salbutamol

Answer 35

palpitations termor hyperglycemia

Question 36

name 2 uses of yohimbine

Answer 36

erectile dysfunction lipolytic agent (low evidence)

Question 37

what kind of drug is phentolamine

Answer 37

reversible non-selective alpha antagonist

Question 38

what is the non selective adrenergic agonist and what receptors does it work on

Answer 38

isoproterenol beta 1 and beta 2

Question 39

name a non-selective beta antagonist

Answer 39

propranolol

Question 40

what are the uses of non-selective alpha antagonists

Answer 40

treating NE secreting tumour

Question 41

3 things should you be aware of before administering epi

Answer 41

arrhythmias hypertension diabetes

Question 42

what two drugs inhibit reuptake of NE from synapse

Answer 42

cocaine tricyclic antidepressants

Question 43

name 4 uses for epi

Answer 43

treat anaphylactic shock cardiac arrest control bleeding limits diffusion of medication by local vasoconstriction

Question 44

prazosin terazosin doxazosin are what kind of drugs

Answer 44

alpha 1 antagonists

Question 45

what kind of drug is phenylephrine

Answer 45

alpha 1 agonist (adrenergic)

Question 46

what type of drug is mirabegron

Answer 46

beta 3 agonist

Question 47

what type of drug is salbutamol

Answer 47

beta 2 agonist

Question 48

what is a example of a beta 3 agonist

Answer 48

mirabegron

Question 49

what is an irreversible non-selective alpha antagonist

Answer 49

phenoxybenzamine

Question 50

what is the use of salbutamol

Answer 50

relieves asthma caused by bronchospasm

Question 51

what is the action of yohimbine

Answer 51

can inc perfusion of certain tissues

Question 52

what is an example of a beta 2 agonist

Answer 52

salbutamol

Question 53

what is dobutamine

Answer 53

beta 1 agonist

Question 54

what is the effect of alpha 2 agonists

Answer 54

less NA release - less sympathetic effects

Question 55

name an adverse effect of alpha 1 antagonists

Answer 55

orthostatic hypotension +reflex inc in HR

Question 56

what drugs inhibits NE breakdown in neurons

Answer 56

MAOIs

Question 57

what kind of drug is phenoxybenzamine

Answer 57

an irreversible non-selective alpha antagonist

Question 58

what does phenylephrine do (a1 agonist)

Answer 58

vasoconstriction - inc BP other a1 effects

Question 59

what are 2 adverse effects of beta 1 agonists

Answer 59

arrhythmias tachycardia

Question 60

what is a pheochromocytoma

Answer 60

NE-secreting tumour

Question 61

how does clonidine work

Answer 61

presynaptic negative feedback that results in decreased NA release

Question 62

what are some adverse effects of clonidine (and other alpha 2 agonists)

Answer 62

hypotension xerostomia sedation

Question 63

what is the effect of miragbegron

Answer 63

relaxation of detrusor muscle

Question 64

what are 3 beta 1 antagonists

Answer 64

metoprolol atenolol bisoprolol

Question 65

what are some adverse effects of blockage of all 3 beta receptors

Answer 65

sedation lethargy erectile dysfunction nightmaress

Question 66

what is clonidine

Answer 66

alpha 2 agonist

Question 67

what are the 3 actions of beta 1 antagonists

Answer 67

dec HR and contractility dec renin secretion dec activation of renin-angiotensin-aldosterone system

Question 68

what are some adverse effects of yohimbine

Answer 68

tachycardia hypertension hypoglycemia