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Flashcards in Anti-Microbials Deck (40):
1

Chemoprophylaxis for meningococcus?

Rifampin

2

Antibiotic with MAO-I properties? (can cause serotonin syndrome)

Linezoid

3

Penicillian - used for?

Mostly gram+ rods (Strep pneumo, strep pyo, actinomyces)

Also spirochetes, meningitdis

4

Penicillian MoA?

bind transpeptidases that cross-link membrane

5

interstitial nephritis - adverse effect of what antibiotic?

Naf-, Oxa, Dicloxa- cillian

6

Psudomembranous colitis and rash - what antibiotic?

Ampicillian/Amoxicillian

7

Ampicillian/Amoxicillian kills?

Enterococci - HELPSS
H flu
E coli
Listeria
Proteus
Salmonella
Shigella

8

Antibiotic for psuedomonas?

Ticarcillian, Pipercillian

9

Cephalosporins do not cover?

LAME
Listeria, Atypicals (chlaydia, mycoplasma), MRSA, Enterococci

10

Only cephalosporin to cover MRSA?

Ceftaroline

11

1st gen Cephaosporin? kills?

Cefazolin. PEcK
Proteus, E coli, Klebsiella

12

2nd generation Cephaosporins? kills?

Cefoxitine, Cefaclor, cefuroxime.
HENS PeCK
H Flu, enterobactor, Neisseria, Serratia, Proteus, E coli, Klebsiella

13

Cephaosporin for meningitis and gonorrhea?

Ceftriaxone

14

Cephaosporin for pseudomonas?

Cefazidime,

CeftAZidime for pseudomonAZ

15

Vit K deficieny with what antimicobes?

Cephaosporin

16

These drugs increase this toxicity of aminoglycosides?

Cephaosporin increase nephrotoxicity

17

Use against gram-negative rods?

Aztreonam

18

Drug that binds to PBP3 is synergistic with this drug?

Aztreonam. Aminoglycosides

19

This PBP binding drug can be given to people with a penicillan allergy?

Aztreonam

20

MoA of drug that is administered with Imipenem?

Cilastatin - inhibitor of renal dehydropeptidase

21

Toxicity of vancomycin?

NOT that common
Nephrotoxicity, Ototoxicity, Thrombophlebitis and Red Man syndrome

22

Affect 30S subunit?
Affect 50S subunit?

Aminoglycosides, Tetracyclines

Chloramphenicol, Clindamycin
Erythromycin
Linezolid

23

Aminoglycosides used for?

aerobic gram-negative rods

24

Aminoglycosides - toxicity?

Mean GNATS caNNOT kill anerobes

"ear shaped" body parts
Nephrotoxicity
Neuromuscular blockade
Ototoxicity
Teratogen

25

Tetracycline used as a diuretic?

Demeclocycline (used for SIADH)

26

Decreased absorption of tetracyclines with?

milk, antacids, divalent cations

27

Clindamycin used to treat?

anaerobes

28

To treat anaerobes above diaphragm vs treat anerobes below diaphragm?

Clindamycin vs metronidazole

29

Sulfonamides - MoA? Used for?

PABA antimetabolites inhibit dihydropteroate synthesis

gram positives, negatives, chlamydia and nocardia

30

Sulfonamides - toxicities?

Sulfa - hemolysis, nephrotoxicity, photosensitivity, kericterus

31

Trimethoprin - MoA? Use?

Inhibit dihydrofolate reductase. Used with Sulfoamides for UTIs, shigella, salmonella, PCP

32

Trimethoprin - toxicities?

Megaloblastic anemia

33

Fluoroquinolones used for? Mech?

gram neg rods (including pseudomonas), neisseria. Inhibit DNA gyrase and topoisomerase

34

Fluroquinolones - toxicities?

tendon rupture, dysglycemia, prolonged QT

35

Metronidazole - use for?

GET GAP
Giardia, entamoeba, trichomonas
Gardnerella, anaerobes (bacteriodes, c diff) and h pylori

36

Metronidazole - do not take?

Alcohol - disulfiram-like reaction

37

TB drugs?

RIPE - rifampin, isonizaid, pyrazinamide, ehtanmbutol

38

MAI drugs?

Azithromycin, rrifampin, ethambutol, streptomycin

39

Leprae drugs?

Dapsone, rifampin

40

isoniazid MoA?

precent mycolic acid synthesis