Anti-Microbials

Question 1

Chemoprophylaxis for meningococcus?

Answer 1

Rifampin

Question 2

Antibiotic with MAO-I properties? (can cause serotonin syndrome)

Answer 2

Linezoid

Question 3

Penicillian - used for?

Answer 3

Mostly gram+ rods (Strep pneumo, strep pyo, actinomyces)

Also spirochetes, meningitdis

Question 4

Penicillian MoA?

Answer 4

bind transpeptidases that cross-link membrane

Question 5

interstitial nephritis - adverse effect of what antibiotic?

Answer 5

Naf-, Oxa, Dicloxa- cillian

Question 6

Psudomembranous colitis and rash - what antibiotic?

Answer 6

Ampicillian/Amoxicillian

Question 7

Ampicillian/Amoxicillian kills?

Answer 7

Enterococci - HELPSS
H flu
E coli
Listeria
Proteus
Salmonella
Shigella

Question 8

Antibiotic for psuedomonas?

Answer 8

Ticarcillian, Pipercillian

Question 9

Cephalosporins do not cover?

Answer 9

LAME

Listeria, Atypicals (chlaydia, mycoplasma), MRSA, Enterococci

Question 10

Only cephalosporin to cover MRSA?

Answer 10

Ceftaroline

Question 11

1st gen Cephaosporin? kills?

Answer 11

Cefazolin. PEcK

Proteus, E coli, Klebsiella

Question 12

2nd generation Cephaosporins? kills?

Answer 12

Cefoxitine, Cefaclor, cefuroxime.
HENS PeCK
H Flu, enterobactor, Neisseria, Serratia, Proteus, E coli, Klebsiella

Question 13

Cephaosporin for meningitis and gonorrhea?

Answer 13

Ceftriaxone

Question 14

Cephaosporin for pseudomonas?

Answer 14

Cefazidime,

CeftAZidime for pseudomonAZ

Question 15

Vit K deficieny with what antimicobes?

Answer 15

Cephaosporin

Question 16

These drugs increase this toxicity of aminoglycosides?

Answer 16

Cephaosporin increase nephrotoxicity

Question 17

Use against gram-negative rods?

Answer 17

Aztreonam

Question 18

Drug that binds to PBP3 is synergistic with this drug?

Answer 18

Aztreonam. Aminoglycosides

Question 19

This PBP binding drug can be given to people with a penicillan allergy?

Answer 19

Aztreonam

Question 20

MoA of drug that is administered with Imipenem?

Answer 20

Cilastatin - inhibitor of renal dehydropeptidase

Question 21

Toxicity of vancomycin?

Answer 21

NOT that common

Nephrotoxicity, Ototoxicity, Thrombophlebitis and Red Man syndrome

Question 22

Affect 30S subunit?

Affect 50S subunit?

Answer 22

Aminoglycosides, Tetracyclines

Chloramphenicol, Clindamycin
Erythromycin
Linezolid

Question 23

Aminoglycosides used for?

Answer 23

aerobic gram-negative rods

Question 24

Aminoglycosides - toxicity?

Answer 24

Mean GNATS caNNOT kill anerobes

"ear shaped" body parts
Nephrotoxicity 
Neuromuscular blockade
Ototoxicity
Teratogen

Question 25

Tetracycline used as a diuretic?

Answer 25

Demeclocycline (used for SIADH)

Question 26

Decreased absorption of tetracyclines with?

Answer 26

milk, antacids, divalent cations

Question 27

Clindamycin used to treat?

Answer 27

anaerobes

Question 28

To treat anaerobes above diaphragm vs treat anerobes below diaphragm?

Answer 28

Clindamycin vs metronidazole

Question 29

Sulfonamides - MoA? Used for?

Answer 29

PABA antimetabolites inhibit dihydropteroate synthesis gram positives, negatives, chlamydia and nocardia

Question 30

Sulfonamides - toxicities?

Answer 30

Sulfa - hemolysis, nephrotoxicity, photosensitivity, kericterus

Question 31

Trimethoprin - MoA? Use?

Answer 31

Inhibit dihydrofolate reductase. Used with Sulfoamides for UTIs, shigella, salmonella, PCP

Question 32

Trimethoprin - toxicities?

Answer 32

Megaloblastic anemia

Question 33

Fluoroquinolones used for? Mech?

Answer 33

gram neg rods (including pseudomonas), neisseria. Inhibit DNA gyrase and topoisomerase

Question 34

Fluroquinolones - toxicities?

Answer 34

tendon rupture, dysglycemia, prolonged QT

Question 35

Metronidazole - use for?

Answer 35

GET GAP Giardia, entamoeba, trichomonas Gardnerella, anaerobes (bacteriodes, c diff) and h pylori

Question 36

Metronidazole - do not take?

Answer 36

Alcohol - disulfiram-like reaction

Question 37

TB drugs?

Answer 37

RIPE - rifampin, isonizaid, pyrazinamide, ehtanmbutol

Question 38

MAI drugs?

Answer 38

Azithromycin, rrifampin, ethambutol, streptomycin

Question 39

Leprae drugs?

Answer 39

Dapsone, rifampin

Question 40

isoniazid MoA?

Answer 40

precent mycolic acid synthesis