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Flashcards in Barbiturates and Anesthetics Deck (43):
1

Barbiturates - suffix? (exception)

barbitol (except thiopental)

2

MoA of barbiturates?

increase duration of Cl- channel opening (barbiDURATes)

3

Barbiturates contraindicated for?

prophyria

4

Barbiturate used for anesthesia induction

Thiopental

5

Barbiturate toxicities: Most worried about?

Repiratory depression

6

Barbiturate - effect on P450?

inducers

7

Barbiturate: OD treatment?

Supportive

8

Benzos - suffix (exception)

-lam, -pam, (chlordiazepoxide)

9

Benzos - MoA

increases frequency of Cl channel (GABAa)opening

10

Benzos - Shorter acting (higher addiction potential)?

triazolam, oxaepam, midazolam

11

Pt comes in with night terrors and sleepwalking. Tx?

Benzos

12

Which has larger effect on respiration - barbs or benzos?

barbiturates

13

Benzo: OD treatment? MoA?

Flumazenil, Competitive antag for GABA receptor

14

MoA of nonbenzodiazepine hypnotics?

Zs (Zolpidem, zalephlon, eszopiclone)
Act via the BZ1 subtype of the GABA receptor

15

Indication of Z-drugs?

Insomnia

16

Side effects of Z-drugs?

Ataxia, headaches, confusion

17

Advantage of Z-drugs over benzos?

Modest dat-after psychomotor depression.
Few amnestic effects.
Lower dependence

18

Anesthetics: What determines induction/recovery times? potency?

decreased blood solubilty = rapid induction
increased lipid solubility = increased potency

19

Potency of anesthetics determined by?

1/MAC (min alveolar concentration at which 50% of the population is anesthetized)

20

Anesthetic with low blood and lipid solubility?

N2O nitrous oxide (low potency and high induction)

21

Anesthetic with high blood and lipid solubility?

Halothane (high potency and slow induction)

22

Inhaled anesthetics - suffix? (exception)

-ane (Nitrous Oxide - N2O)

23

Anesthetic Toxicity: hepatoxicity

halothane

24

Anesthetic Toxicity: nephrotoxicity

methoxyflurane

25

Anesthetic Toxicity: proconvlusant

enflurane

26

Anesthetic Toxicity: malignany hyperthermia

All but N2O

27

Anesthetic Toxicity: trapped gas in body

N2O

28

Intravenous anesthetic classes (5)

Barbs, Benzos, Ketamine, Opioids, Propofol

29

Barb with high potency and rapid entry into brain. Used to induce anesthesia. How is effect terminated?

Thiopental. Rapid redistribution into tissue

30

Benzo used for endoscopy. Treat OD with?

Midazolam. Flumazenil

31

IV anesthetics that blocks NMDA receptors. Stimulation of? Side effects?

Ketamine. Stimulate cardiovascular system. Hallucinations

32

Opioid used during general anesthesia (2)

Morphine and Fentanyl

33

Used for sedation in ICU. Rapid anesthesia induction. MoA?

Propofol. Potentiates GABAa.

34

Local Anesthetics: esters?

procaine, cocaine, tetracaine

35

Local Anesthetics: amides?

LIdocaIne, MepIvacaIne, bupIvacaIne

36

Local Anesthetics: MoA?

The -caines. Block Na channels by binding to inner portion of ACTIVE channels

37

Local Anesthetics: enhance location action by?

The -caines. giving with vasoconstrictors (NE)

38

Local Anesthetics: why need more in infected tissue?

The -caines. Acidic tissue charges molecules, can't go through membrane

39

Local Anesthetics: Nerves most affected? Order of sensation loss with administration?

The -caines. Small then myelinated. pain, temperature, touch, pressure

40

Local Anesthetics: toxicity?

The -caines. CNS excitation

41

Local Anesthetics: cardiovascular toxicity with?

Bupivacaine

42

Local Anesthetics: arrhythmias?

cocaine

43

Alcoholic comes in with DTs. Tx?

Benzos