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Flashcards in Heme Deck (23):
1

Coagulant used during pregnancies for for immediacy. Follow what lab?

Heparin. PTT

2

Heparin OD. Mech of antidote?

Protamine sulfate. Positively charged molecule that binds heparin

3

LMWH. Names? vs heparin?

Enoxaparin, dalteparin. Act more on factor 10, longer half-life, better bioavailabilty. Not easily reversible

4

HIT?

Heprain-induced thrombocytopenia. development of IgG antibodies against heparin-PF4 complex which activates platelets.

5

Pt with HIT. Alternative? Mech?

Lepirudin, bivalirudin. Inhibits thrombin

6

Used from chronic anticoagulation. MoA?

Warfarin. Interferes with gamma-carboxylation of vit.K clotting factors 2,7,9,10,C,S. Slow developing anticoagulation

7

Anticoagulant metabolized by P-450s. Long half-life. Monitor what pathway?

Warfarin. Monitor PT.

8

Do not use this anticoagulant in pregnancy. Reversal in mild OD? severe OD?

Warfarin. Vit K. Fresh frozen plasma

9

Drug that causes cutaneous necrosis. Mech?

Warfarin. Depletes protein C/S.

10

Heparin:
structure,
route,
site of action,
onset time,
duration of action,
function in vitro?
OD tx?
monitor what?
crosses placenta?

structure - Large negatively charged particle
route - IV/SC
site of action - blood
onset time - seconds
duration of action - hours
function in vitro - yes
OD tx - protamin sulfate
monitor what - PTT
crosses placenta - no

11

Warfarin
Heparin:
structure,
route,
site of action,
onset time,
duration of action,
function in vitro?
OD tx?
monitor what?
crosses placenta?

structure - small lipophillic molecule
route - oral
site of action - liver
onset time - slow (limited by half-lives of factors)
duration of action - days
function in vitro - no
OD tx - Vit K or fresh frozen plasma
monitor what - PT
crosses placenta - yes (teratogenic)

12

INR is same thing as?

PT

13

Thrombolytics? Tx OD with?

alteplase, reteplase, tenecteplase. Aminocaproic acid.

14

Drug used in severe MI or early PE. MoA?

Thrombolytics. cleaves thrombin and fibrin

15

Asprin - affect on BT, PT, PTT? Toxicities?

Only increases BP.
Tinnus
Gastic ulceration
Reye's

16

Drugs that inhibit expression of GP IIb/IIIa?

Clopidrogrel
Ticlodipine
Prasugrel
ticagrelor

17

Pt with coronary stenting - use these drug.

ADP receptor antagonists:
Clopidrogrel
Ticlodipine
Prasugrel
ticagrelor

18

ADP receptor antagonists - toxicities?

Neutropenia

19

Pt with intermittant claudication. Use this as angina prophylaxis/stroke prevention?

cilostazol (Claudication Intermittant), dipyridamole.

20

Pt with TIAs is put on a drug to decrease stoke chance. Comes in with headache, flushing, hypotension. MoA of drug?

cilostazol, dipyridamole.
1) Phosphodiesterase III inhibitor - increases cAMP in platelets, inhibiting aggregation.
2) inhibits adenosine uptake - more adenosine increases cAMP in platelets, inhibiting aggregation

21

Use in pts with acute coronary syndrome?

GP IIb/IIIa inhibitors. Abciximab, eptifibatide, tirofiban

22

Used in treatment of acute bleeding in pt with hemophilia? Mech?

Aminocaproic acid. Inhibits firbinolysis

23

Used in pt with sickle cell? Also used for?

Hydroxyurea (increase HbF). Also used to myeloid neoplasms (inhibits DNA synthesis)