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Flashcards in ONC Deck (12):
1

Cancer Drug that works during:
G1?
S?
G2?
M?

G1? none
S? antimetabolities/etoposide
G2? bleomycin, etoposide
M? Vinca alkaloids and taxols

2

Decreases thymidine synthesis?

Methotrexate
5FU

3

Decreases purine synthesis?

6-MP

4

crosslink DNA

Alkylating agents, cisplatin

5

Intercalate DNA?

Dactinomycin, doxorubicin

6

inhibits topoisomerase II?

etoposide, doxorubicin

7

inhibits microtubule formation?
inhibits microtubule disassembly?

Vinca alkaloids, paclitaxel

8

Methotrexate: uses?

Cancers: Leukemias, lymphomas, chorioCA, osteoCA
non: cancer: abortion, ectopic pregnancy, RA, psoriasis

9

MTX can cause myelosuppression. Reversible with? Drug that causes myelosuppression not reversible in same way?

Leucovorin. 5FU

10

Cancer pt comes in with microvesicular fatty change in liver. Cause?

MTX

11

Use for topical cancers (basal cell CA, etc). Side effect?

5-FU. Photosensitivity

12

5FU MoA?

Pyrimidine analog, complexes folic acid, inhibiting formation of dTMP.