Flashcards in Neuro Pharm - Opioids and Glaucoma Deck (29):
MoA of glaucoma drug that cannot be used in closed-angle glaucoma.
Epinephrine - decreases aqueous humor synthesis via vasoconstriction
MoA of Glaucoma drug that can cause itching or foreign body sensation of eye?
Brimonidine -a2 agonist - decreases aqueous humor synthesis
B-blockers used in glaucoma?
Timolol, Betaxolol, Carteolol
MoA of diuretic used for glaucoma?
Acetazolamide - decreases aqueous humor synthesis via inhibition of carbonic anhydrase
MoA of direct cholinomimetics (2) used for glaucoma?
Pilocarpine and cabachol. Increased outfow of aqueous humor via contraction of ciliary muscle and opening of trabecular meshwork
Glaucoma drugs that may lead to miosis and cyclospasm
Pilocarpine and carbachol
cyclospasm - contraction of ciliary muscle
Glaucoma drug used in emergencies?
Indirect cholinomimetics used for glaucoma?
MoA of prostaglandin used used for glaucoma?
Lantanoprost. PGF-2alpha. Increases outflow of aqueous humor
Glaucoma drug that may darken color of Iris?
Opioids - tolerance does not develop to?
miosis and constipation
Opioid used for cough?
Opioid used for diarrhea (2)
Loperamide and diphenoxylate
Pulmonary indication for opioid use?
acute pulmonary edema
Opioid used for addiction programs?
naloxone and naltrexone
Opioid for diarrhea
Opioid used for cough
MoA for opioids? (NTs affected)
Opens K, close Ca - decrease transmission of ACh, 5HT, NE, glutamate and substance P
MoA of opioid used for severe pain (migrane, labor)?
Butrophanol. Mu-partial agonist and kappa-agonist.
Opioid that is not not easily reversed with naloxone?
Causes less respiratory depression than other opioids?
Weak Opiod agonist?
MoA for opioid used for chronic pain?
Tramadol. Opioid ag that inhibits 5HT and NE reuptake
Overview: classes of drugs that
1) decrease aqueous humor synthesis
2) increase outflow
1) epinephrine, a2-agonists , b-blockers, diuretics
2) direct cholinomimetics, indirect cholinomimetics, prostaglandins
Opioid that can decrease seizure threshold?