Neuro Pharm - Opioids and Glaucoma Flashcards Preview

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Flashcards in Neuro Pharm - Opioids and Glaucoma Deck (29):
1

MoA of glaucoma drug that cannot be used in closed-angle glaucoma.

Epinephrine - decreases aqueous humor synthesis via vasoconstriction

2

MoA of Glaucoma drug that can cause itching or foreign body sensation of eye?

Brimonidine -a2 agonist - decreases aqueous humor synthesis

3

B-blockers used in glaucoma?

Timolol, Betaxolol, Carteolol

4

MoA of diuretic used for glaucoma?

Acetazolamide - decreases aqueous humor synthesis via inhibition of carbonic anhydrase

5

MoA of direct cholinomimetics (2) used for glaucoma?

Pilocarpine and cabachol. Increased outfow of aqueous humor via contraction of ciliary muscle and opening of trabecular meshwork

6

Glaucoma drugs that may lead to miosis and cyclospasm

Pilocarpine and carbachol

cyclospasm - contraction of ciliary muscle

7

Glaucoma drug used in emergencies?

pliocarpine

8

Indirect cholinomimetics used for glaucoma?

Physostigmine, Echothiophate

9

MoA of prostaglandin used used for glaucoma?

Lantanoprost. PGF-2alpha. Increases outflow of aqueous humor

10

Glaucoma drug that may darken color of Iris?

Latanoprost

11

Opioids - tolerance does not develop to?

miosis and constipation

12

Opioid used for cough?

Dextromethorphan

13

Opioid used for diarrhea (2)

Loperamide and diphenoxylate

14

Pulmonary indication for opioid use?

acute pulmonary edema

15

Opioid used for addiction programs?

methadone

16

Anti-opioids (2)

naloxone and naltrexone

17

Meperidine?

Opioid

18

diphenoxylate?

Opioid for diarrhea

19

fentanyl?

Opioid

20

dextromethorphan?

Opioid used for cough

21

MoA for opioids? (NTs affected)

Opens K, close Ca - decrease transmission of ACh, 5HT, NE, glutamate and substance P

22

MoA of opioid used for severe pain (migrane, labor)?

Butrophanol. Mu-partial agonist and kappa-agonist.

23

Opioid that is not not easily reversed with naloxone?

Butorphanol

24

Causes less respiratory depression than other opioids?

Butrophanol

25

Weak Opiod agonist?

Tramadol

26

MoA for opioid used for chronic pain?

Tramadol. Opioid ag that inhibits 5HT and NE reuptake

27

Overview: classes of drugs that
1) decrease aqueous humor synthesis
2) increase outflow

1) epinephrine, a2-agonists , b-blockers, diuretics
2) direct cholinomimetics, indirect cholinomimetics, prostaglandins

27

Opioid that can decrease seizure threshold?

Tramadol

28

drug with similar MoA to butorphan?

Pentazocine