Epilepsy Drugs Flashcards Preview

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Flashcards in Epilepsy Drugs Deck (31):
1

MoA of 1st line drug for absence seizures?

Ethosuximide. Blocks thalamic T-type Ca channels

2

MoA of first line drugs (2) for acute status epilepticus?

Diazepam/Lorazepam. Increase GABAa

3

1st and 2nd line drugs used for seizures of eclampsia?

1) MgSO4
2) Benzos (diazepam and lorazepam)

4

MoA for 1st line drug for Simple partial

Carbamazepine. Increases Na channel inactivation

5

Drug for trigeminal neuralgia?

Carbamazepine

6

MoA for 1st line drug for complex partial

Carbamazepine. Increases Na channel inactivation

7

1st line drugs for Tonic-Clonic (3)

Pheytoin, Carbamazeine, Valproic Acid

8

MoA of 1st line drug for status epilepticus prophylaxis?

Pheytonin.
1) Increases Na channel inactivation
2) Inhibition of Glutamate release

9

Parenteral version of phenytoin?

fosphenytoin

10

Carbamazepine - first line drug for? (4)

Simple, Complex, tonic-clonic seizures and tigeminal neuralgia

11

Lamotrigine - MoA? Used for what seizures?

Blocks voltage gates Na channels
Simple, Complex, tonic-clonic seizures

12

Gabapentin - MoA? Used for what seizures?

Inhibits high voltage-activated Ca channels. Simple, Complex, tonic-clonic seizures

13

Gabapentin also used for (other than seizures? (4)

Peripheral neuropath, post-herpetic neuralgia, migranine prophylaxis, bipolar

gaBaPeNtiN (bipolar, migraine Prophyaxis, neuropathy, neuralgia)

14

Topiramate - MoA? Used for what seizures?

1) Blocks voltage gates Na channels
2) Increases GABA
Simple, Complex, tonic-clonic seizures

15

Antiseizure drugs also used for migraine prevention?

Topiramate and Gabapentin

16

Drug used as 2nd line for absence seizures?

Vaproate

17

Valproate MoA? Used for what seizures?

1) increases Na channel inactivation
2) Increases GABA
Simple, Complex, tonic-clonic seizures, absense, and myoclonic

18

Drug used in myoclonic seizures?

Valproate

19

Tigabine - MoA? Used for what seizures?

Inhibits GABA reuptake. Simple and Complex seizures

20

Vigabatrin -MoA? Used for what seizures?

Irreversibly inhibits GABA transaminase, increasing GABA
Used for simple and complex

21

Levetriacetam - MoA? Used for what seizures?

Unknown. Simple, complex, tonic-clonic

22

Antiseizure drugs that cause malaise and fever followed by rapid onset of oral, genital, and ocular purpuric macules

SJS. Lamotrigine, Carbamazepam, Ethosuximide (CLE)

23

Antiseizure Drug that causes SIADH

Carbamazepam

24

Antiseizure Drug that causes agranulocytosis or aplastic anemia?

Carbamazepine

25

Antiseizure Drugs that cause induction of P450s

Carbamazepine, Phenobarbital

26

Ethosuximide side effects?

EFGH
Ethosuximide
Fatigue
GI
Headache

27

Phenytoin - uniqure side effects? (8)

PATHS LONGS
Phenytoin
megaloblastic Anemia (decreases folate absorption)
Teratogenesis
Hirsutism
SLE
Lymphadenopathy
osteopenia
Nystagmus
gingival hyperplasia
SJS,

28

Antiseizure Drug that can cause fatal hepatotoxicity?

Valproic Acid

29

Antiseizure Drug that cause mental dulling, kidney stones and weight loss?

Topiramate

30

Antiseizure drug that is metabolized to phenobarbital?

Primidone

30

Antiseizure drug that also which class of antriarrythmic?

Pheytoin. Class 1B