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Flashcards in Repro Drugs Deck (33):
1

Drug given in pulsitile fashion for infertitiy. MoA?

Leuprolide. GnRH analogue

2

Pt with uterine fibroids. Side effects of drug?

Leuprolide. Nausea and vomiting

3

Pt with prostate cancer - 2 drug combo?

leuprolide and flutamide

4

Drugs that block testicular production of testosterone?

Ketoconazole, Spirolactone (Shoot and Kill testies)

5

Drugs that block binding of DHT/T to receptor?

Flutamide, cyproterone, spirolactone (SPI-CY FLUTe)

6

Drugs that block Anti Pit secretion of FSH/LH?

OCP, danazol

7

Drug that block aromatase?

Anastrozole

8

Drugs that block estrogen binding to receptor?

Fulvestrant

9

Pediatric with burns. Possible consequence of giving this post-burn drug to children?

Testosterone. Closure of epiphyseal plate (also up LDL, down HDL)

10

Adult pt with hypogonadism. Side effect of drug?

Testosterone. Increases LDL and decreased HDL (can close epipyseal plates in children)

11

MoA of drug that makes boobs bigger (women) and decreases hair loss (men)

Finasteride. 5a-reductase inhibitor (Five-Alpha = FinAsteride)

12

Inhibits 17,20 desmolase. Use in this disease. Similar drug?

Ketoconzaole. PCOS to prevent hirsutism. ALso spirolactone

13

Pt with androgen-dependent prostate cancer?

Estrogens (mestranol)

14

Increases risk of clear cell carconoma in women?

DES (estrogen)

15

Contraindications for estrogen?

DVT, ER-positive breast cancer

16

SERM used for infertility. MOA

Clomiphene - partial ag. Used to block E feedback in pituitary, increasing FSH/LH.

17

SERM used for older female with low bone density? MOA

Raloxifene - agonist in bone (prevent osteoporosis)

18

MoA of SERM used in breast cancer. Risk?

Tamoxifen. Antagonist on breast, agonist in uterus (increase risk of endometrial cancer)

19

Postmenopausal women with breast cancer. MoA of Drugs?

Anastrozole, exemestane (aromatase inhibitors)

20

Reduces growth and increases vascularization of endometrium?

Progestins

21

Pt comes in with Heavy bleeding, nausea, vomiting, and without an appetite after abortion. MoA of Drug given?

Mifepristone. Competitive inhibitor of progesterone

22

Mifepristone given with what other drug?

Misoprostol (PGE1)

23

Do not given to smokers, estrogen-dependent cancer pts, or pts with clotting disorder?

OCP (progestins, estrogens)

24

OCP - MoA?

Estrogen/Progesterone inhibits LH/FSH surge -> no ovulation

25

b-HCG MoA?

produces LH

26

MoA of drug to reduce uterine contractions?

Terbutaline. B2-agonist.

ter-B(2ag) U(terus)-aline

27

MoA of drrug to treat older male pt with trouble urinating.

Tamulosin. alpha-1a,d-antag for BPH. Selective for prostate receptors.

28

MoA of drugs to used treat prostate cancer.

SilDENAFIL, VarDENAFIL (fill the penis). inhibits phosphodiesterase 5 increasing cGMP, relaxing smooth muscle and increasing blood flow.

29

Pt with heatburn, hypotension, and impaired headache? Side effects of?

sildenafil and vardenafil

30

distortions in blue-green color vision. Side effect of?

Sildenafil and vardenafil

31

Used for endometriosis and angioedema?

Danazol

32

Pt with history of swelling (runs in family) on a drug that has increased acne, hirsutism, and decreased HDL?

Danazol

33

Hepatoxicty is a side effect of this drug that is a partial receptor at androgen receptors?

Danazol