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Flashcards in Lung Pharm Deck (23):
1

1st generation vs 2nd generation H1 blockers? (and names)

1st: Diphenhydramine, dimenhydrinate, chlorpheniramine (-en---ine or -en---ate)
2nd: lortadine, fexofenadine, desloratadine, cetirizine (-adine)

2nd gen less sedating because of decreased entry into CNS

2

1st gen H1 blockers - uses? (vs 2nd generation)

allergy, motion sickness, sleep aid (vs allergy)

3

Toxicities of 1st generation h1-blockers vs 2nd

sedation, antimuscarininc, anti-a-adrenergic vs less sedating

4

Bronchoconstriction caused by 2 general mechanisms?

inflam or increased PSNS

5

Acute exacerbation of asthma. Use (drug and mech?)

albuterol (b2-agonist)

6

Pt taking a drug for prophylaxis for asthma. Gets a tremor and arrhythmia. Drug?

Salmeterol/formoterol (B2-ags)

7

Asthma drug (and class) that has narrow therapeutic index? toxicities?

Theophylline (methxanthines). Can cause cardiotoxicity (arrhythmias) and neurotoxicites (nervousness/seizures)

8

Drug that blocks vasoconstriction increases vasodilation of airway? Mech?

Theophylline.
1)Inhibits PDE and increases cAMP (increase bronchialdilation)
2)blocks adenosine (decreases bronchoconstriction)

9

Antimuscarinic used in asthma?

Ipratropium (I pray to breath soon) and tiotropium

10

1st line for chronic asthma?

Beclomethasone, fluticasone (steroids)

11

Good for asprin induced asthma? Mech?

Anti-leukotrienes.
1st line: Montelukast and zafirlukast (block LT receptors)
2nd line: zileuton (block lipooxygenase)

12

Specifically blocks conversion of arachidonic acid to leukotrienes? Mech?

Zileuton. 5-lipoxygenase.

13

Used in allergic asthma resistant to inhaled steroids.

Omalizumab. anti-IgE antibody

14

N-acetylcystine - functions?

1) antidote for aspirin OD
2) expectorant - losens mucous plugs in Cystic Fibrosis pts

15

Thins respiratory secretion but does not suppress cough?

Guaifenesin

16

Used to treat pulmonary arterial HTN. Mech?

Bosetan. Antag for endothelin-1 receptors, decreasing pulmonary vascular resistance

17

Opioid for cough?

Dextreomethorphan

18

non-prescription nasal decongestants? Mech? toxicities?

pseudoephedrine, phenylephrine. a-agonistic HTN and CNS stumulant

19

Used in asthma challenge testing?

Methacholine

20

Asthma drugs?

ASSTHMAA
albuterol
Salmeterol/fomoterol
Steroids
Theophylline
Histamine release blockers
Muscarinic antags
Anti-LTs
Anti-IgE antibodies

21

Asthma drugs?

ASSTHMAA
albuterol
Salmeterol/fomoterol
Steroids
Theophylline
Histamine release blockers
Muscarinic antags
Anti-LTs
Anti-IgE antibodies

22

Pt comes in with hypokalemia and U-waves. Took too much of?

B-ag like albuterol. (B-ags drive K into cells and can destabilize cardiac membranes, resulting in U-waves)

23

OD on theophylline. Tx?

B-blocker