Flashcards in GI Pharm Deck (23):
Pt with peptic ulcer comes in with gynecomastia, confusion. MoA of these side effects?
Cimetidine (H2-blocker). Has antiandrogen effects (prolactin release, impotence etc) and can cross BBB (confusion, dizziness)
Pregnant woman with acid reflux. Better not give?
Cimetidine (can cross placenta). Use other H2 blockers
Pt taking these drugs may have a low renal excretion of creatinine?
Cimetidine and Rantidine
H2 Blockers. Reversibly Block H2 receptors on parietal cells.
PPIs. Irreversibly ATPase in parietal cells.
Pt on drug comes in with decreased serum Mg and C. difficle. Increased risk for?
PPI toxicities. Hip fracture
Pt with ulcer or traveller's diarrhea. Can give? (2). MoA?
Bismuth, sucralfate. Bind to ulcer base, providing physical protection and allowing HCO3 secretion.
Used to induce labor but contraindicated in women of childbearing age because can cause abortion. Other uses?
Misoprostol. PGE analog. Also used to prevent NSAID-induced ulcers and maintain the PDA.
Pt with acute variceal bleeds. Drug can also be used to treat what?
Octreotide. Somatostatin analog. VIPoma, carcinoid tumors
Pt with acomegaly. Side effects of drug?
Octreotide. Nausea, Steatorrhea
Pt with reflux. Tx causes hypoK.
Pt with reflux. Tx causes muscle weakness and constipation. At risk for?
Aluminum hydroxide antacid (aluMINIUM amount of feces). Risk for seizure.
Pt with reflux. Tx causes complaints of diarrhea. PD shows hyporeflexia and hypotension. Pt may get?
Mg hydroxide. Cardiac arrest.
Pt with reflux. Taking antibiotics but they dont seem to be working. What drug/what antibiotic?
Ca carbonate can chelate tetracyclines
Pt with hepatic encephalopathy. Can give what osmotic laxative? MoA?
Lactulose. Gut flora break it down into lactic and acetic acid. Promotes excretion as NH4.
Drug that is both a laxative and an antacid?
RA/Crohn's/UC Pt comes in with cough. Tests positive for caseating granulomas? Drug?
infliximab. TNFa inhibitior. increased risk of infection like TB reactivation
Male pt comes in with Oligospermia after being put on a drug.
Where is the drug activated?
Sulfasalazine. Activated by colonic bacteria
Sulfasalazine: Use and MoA?
Sulfasalazine. Combo of sulfapyridine (anti-bacterial) and 5-ASA (antiinflam). Used in UC and crohn's
Antiemetic. 5HT3 antagonist.
"Feeling queasy? Keep ON-DANCing with Ondansetron"
Diabetic with gastroparesis. MoA of drug?
Metaclopromide. D2 receptor antag. Increases tone of LES.