UWORLD NEURO/PSYCH PHARM Flashcards Preview

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Flashcards in UWORLD NEURO/PSYCH PHARM Deck (42):
1

Pt with 6-12 Hz tremor of upper extremity over the last 10 years. Tx?

Essential Tremor. Beta Blocker

2

Migraine drug that can cause hypertensive crisis?

sumatriptan

3

Sumatriptan MoA

5HT1b/1d AGONIST

4

MoA MG drugs?

Pyridostigmine. Carbamylates AChE to inactivate it.

5

Drugs that phosphorylate AChE?

nerve gases. Sarin.

6

Depressants that can cause glaucoma?

TCAs - anticholinergic effects

7

Use and MoA of Cyclobenzaprine?

Muscle relaxant. blocks ACh.

8

AChE inhibitor OD. Tx?

parlidoxime. Reactivates AChE (decreases ACh)

9

OD on anticholinergic. TX?

physostigmine.

10

No wine/cheese with what drugs?

MAO-I

11

Antimuscarinic used in PD?

Benztropine, Trihexyphenidyl

12

Ocular pain with halos?

Glaucoma

13

2 distinct ways to Treat Parkinsons?

increase DA, decrease ACh

14

AMPH MoA?

reverses reuptake transporter

15

Don't give these drugs to a bipolar patient in a mania phase

TCA

16

Mood stablizing drugs:
Principal agents (2)?
anti-seizure?
atypicals?
other class?

Li, valproate
Carbamazapam
Olanzapine, clozapine
Benzos

17

Pt with controlled MG, comes in with MG symptoms. Give edrophonium. If symptoms improve? If they don't?

1) Give more drug
2) cholinergic crisis. Stop drugs

18

Penicillans MoA?

bind to transpeptidases (PBPs) that crosslink cell wall. Do not bind to wall itself.

19

Organophosphates/pesticides MoA?

irreversible inhibit AChE -> increases ACh

20

Organophosphate poisoning. Problem with atropine? DoC?

Will only reverse effects at Muscarinc receptors (no effect on muscle). Pralidoxime is DoC - reactivates AChE.

21

Advantages/Disadvatages of buspirone?

no hypnotic, sedative, or euphoric effects but takes 2 weeks to work

22

GABA A vs B vs C? (location, type of channel)

Brain, ion channel
Brain G-protein
Retina, Ion channel

23

Tx: Malignant Hypertension vs Neroleptic Malignant syndrome vs Serotonin Syndrome

Dantrolene vs Dantrolene/D2 ags vs Cyproheptadine (5HT2 antag)

24

Dantrolene blocks what Receptor?

Ryanodine

25

All inhaled anesthetics have this undesirable effect?

increase blood flow to Brain increasing ICP

26

Anti-depressant without any sexual side effects?

Bupropion

27

Drugs that can result in serotonin syndrome:
Analgesic?

tramadol

28

How secondary MoA that causes antibiotic to cause serotonin syndrome?

Linezoid. Weak MAO-I activity

29

Supplement that increases peripheral metabolism of L-dopa?

Multivitamin, specifically Vit B6

30

Chemoprophylaxis for menigococcus?

Rifampin

31

Entacopone and Tolcapone. MoA?

COMT inhibitors. Decrease peripheral degradation of L-Dopa.

32

Opioids that are weak Mu-agonists (can trigger withdrawl in pts high on opioids).

butrorphanol, pentazocine

33

Antiseizure drug that is metabolized to phenobarbitol?

primidone

34

Psychosimulant drug for narcolepsy?

modafinil

35

Drugs that can result in serotonin syndrome:
Anti-emetic?

5HT3 receptor antagonist (ondansetron)

36

Drugs that can result in serotonin syndrome:Antibiotic?

Linezoid

37

Drugs that can result in serotonin syndrome: Neuropsychiatric?

Triptans

38

Benzos that will increase fall risk?

Long acting benzos:
Cblordiazepoxide, Clorazepate, Diazepam, flurazepam

39

To treat TCA-related cardic problems?

NaHCO3

40

Effect of ACh on endothelial cells?

release of NO

41

Li toxicity in increased what what type of drugs?

NSAIDs, Thiazides, ACE inhibitors

42

MoA of TCA cardiotoxicity?

blocks cardiac Na channels