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Flashcards in anti-virals Deck (120)
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1

moa of oseltamivir

inhibits influenze neuraminidase - decreases release of progeny viruses

2

moa of zanamivir

inhibits influenza neuraminidase - decreases release of progeny viruses

3

treatment of influenza A and B

oseltamivir
zanamivir
MIVIRs

4

prevention of influenza A and B

oseltamivir
zanamivir
MIVIRs

5

MOA of acyclovir/famciclovir, valacyclovir

guanosine analougs
monoPi by HSV/VZV thymidine kinase and not uninfected cells
triphosphate by host enzymes
inhibits viral DNA polymerase by chain termination

6

treatment of HSV and VZV

acyclovir, famciclovir, valacyclovir

7

what virsus foes acyclovir, famiciclovir and valacyclovir work against?

HSV, VZV, weak against EBV
NO CMV

8

treatment of HSV induced mucocutanoeus and genital lesiosn

acyclovir
famiciclovir
valacyclovir

9

treatment of HSV encephalitis

acyclovir
famiciclovir
valacyclovir

10

use of acyclovir in immunosuppressed indvls

prhophylaxis

11

doc at herpes zoster

famiciclovir

12

toxo of acyclovir

obstructive crystalline nephropathy
acute renal failure

13

how do prevent toxo of acyclovir

hydration to prevent obstructive crystalline nephropathy/acute renal failure

14

how do HSV and VZV resists acyclovir

muta viral thymidine kinase

15

moa fo ganciclovir

5'monophosphate formed by a CMV viral kinase
guanosine analog
triphosphate formed by cellular kinases
inhibits viral DNA polymerase by chain termination

16

doc of CMV, especially in immunocmopromised

ganciclovir

17

toxos of ganciclovir

leukopenia
neutropenia
thrombocytopenia
renal toxicity

18

which is more toxic to host cells, acyclovir of ganciclovir

ganvivclovir - leuko/neutron/thrombocytopenia

19

moa of resistane of ganciclovir

mutated viral kinase

20

moa of foscarnet

viral DNA/RNA polymerase inhibitor and HIV reverse transcriptase inhibitor
binds to pyroFOSphaste binding site
NO ACTIVATION BY KINASE REQUIRED

21

what is foscarnet used for

CMV retinitins when ganciclovr doesn't work
acyclovir resistant HSV

22

toxo of foscarnet please

nephrotoxicity
electrolyte abnormalities: hypo/hyperCa AND hypo/hyperPO4 and hypoK and hypoMg
electorylte abnormalities can lead to seizures

23

MOA resistance foscarnet

mutated DNA plymerase

24

MOA cidofovir

preferentially inhibits viral DNA polymerase
DOES NTO REQUIRE PHOS BY KINASE

25

which two drugs for CMV do not require pi by kinase

foscarnet and cidofovir

26

what is the use of cidofovir

CMV retinitis in immunocompromised patients
acyclovir restiant HSV

27

toxo of cidofover

nephrotoxocity

28

how to prevent nephrotoxicity of cidofovir

give with probenecid and IV saline to decrease nephrotoxicity of cidofovir

29

how to treat HIV

three drug regimen to prevent resistance
2 x NRTIs and 1 x of a) NNRTI, b) integrase inhibitor or c( protease inhibitors

30

list the protease inhibitors

NAVIRS
atazanavir
darunavir
fosamprenavir
indinavir
lopinavir
ritonavir
saduinavir