Flashcards in myco/fungi/scabies/helmninth Deck (82)
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1
prophylaxis for mycobacterium tuberculosis
isoniazid
2
treatment of mycobacterium tuberculosis
RIPE
rifampin
isoniazid
pyrazinamide
ethambutol
3
prophylaxis of mycobacterium avium-intracellulare
azithromycin
rifabutin
4
treatment for mycobacterium avium-intracellulare
azithromycin or clarithyromycin and ehtambutol
can add rifabutin or ciprofloxacin
5
azithromycin/clathrithromycin and ethambutol and can add rifabutin or ciprofloxacin for?
treatment for mycobacterium avium-intracellulare
6
treatment fo mycobacterium leprae - tuberculoid form
long term with dapson and rimapine
7
treatment of mycobacterium leprae - lepromatous form
dapsone, rifampin, clofazimine
8
treat ? with this: dapson, rifampine, clofazimine
mycobacterium leprae
9
what is the MOA of rifampin and rifabutin
inhibit DNA dependent RNA polymerase
10
what antimycobacterial drugs inhibit DNA dependent RNA polymerase
rifampin and rifabutin
11
what is the clinical use of rifampin and rifabutin?
m TB
delay resistance to dapson @ M leprae
meningococcal prolylaxis and chemoprophylaxis in contacts of children with HIB
12
toxo of rifampin and rifabutin
minor hepatotoxicity and increases P450
orang body fluids
13
which rifamycin is preferred in HIV patients and why
rifabutin bc stimulates cytochrome P450 less
14
what is the mechanism of resistance of rifampin and rifabutin
mutationed reduces drug binding to RNA polymerase
monotherapy - increased resistance
15
what are rifampins FOUR Rs?
RNA polymerase inhibitor
ramps up microsomal cytP450
red/orange body fluids
rapid resistance if used alone
16
what is the MOA of isoniazid
decreases synthesis of mycolic acids
bacterial catalase peroxidase encoded by KatG is needed to activate to its active metabolie
17
what is isoniazid used for
m TB
ONLY antimycobacterial that can be used on its own
18
what are the toxicities of isoniazid
neurotoxicity - can prevent with B6
hepatotoxicity
19
what is the mechanism of resistance of isoniazid
mutations that lead to underexpression of KatG
20
how can you decrease the neurotoxicity of isoniazid
give em B6
21
what is the MOA of pyrazinamde
unknown
22
what is the cxl use of pyrazinamide
M Tb
23
what are the a/se of pyrazinamde
hyperuricemia
hepatotoxcity
24
what is the MOA of ethambutol
decreases carbohydrate polymerization of mycobacterium cell wall by blocking arabinosyltransferase
25
what is cilinical sue of ethambutol
m TB and with azithromycin/clarithromycin for MAC (Can add rifabutin or ciprofloxacin)
26
a/se of ethambutol please
optic neurpathy - red gree colour blindness
27
what is the MOA of amphotericin B
binds ergosterol to form membrane pores that allow electrolytes through
28
clinical use of amphotericin B
serious systemic mycoses
29
treat Cryptococcus meningitis!
amphotericin B and flucytosine
30
