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Flashcards in myco/fungi/scabies/helmninth Deck (82)
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1

prophylaxis for mycobacterium tuberculosis

isoniazid

2

treatment of mycobacterium tuberculosis

RIPE
rifampin
isoniazid
pyrazinamide
ethambutol

3

prophylaxis of mycobacterium avium-intracellulare

azithromycin
rifabutin

4

treatment for mycobacterium avium-intracellulare

azithromycin or clarithyromycin and ehtambutol
can add rifabutin or ciprofloxacin

5

azithromycin/clathrithromycin and ethambutol and can add rifabutin or ciprofloxacin for?

treatment for mycobacterium avium-intracellulare

6

treatment fo mycobacterium leprae - tuberculoid form

long term with dapson and rimapine

7

treatment of mycobacterium leprae - lepromatous form

dapsone, rifampin, clofazimine

8

treat ? with this: dapson, rifampine, clofazimine

mycobacterium leprae

9

what is the MOA of rifampin and rifabutin

inhibit DNA dependent RNA polymerase

10

what antimycobacterial drugs inhibit DNA dependent RNA polymerase

rifampin and rifabutin

11

what is the clinical use of rifampin and rifabutin?

m TB
delay resistance to dapson @ M leprae
meningococcal prolylaxis and chemoprophylaxis in contacts of children with HIB

12

toxo of rifampin and rifabutin

minor hepatotoxicity and increases P450
orang body fluids

13

which rifamycin is preferred in HIV patients and why

rifabutin bc stimulates cytochrome P450 less

14

what is the mechanism of resistance of rifampin and rifabutin

mutationed reduces drug binding to RNA polymerase
monotherapy - increased resistance

15

what are rifampins FOUR Rs?

RNA polymerase inhibitor
ramps up microsomal cytP450
red/orange body fluids
rapid resistance if used alone

16

what is the MOA of isoniazid

decreases synthesis of mycolic acids
bacterial catalase peroxidase encoded by KatG is needed to activate to its active metabolie

17

what is isoniazid used for

m TB
ONLY antimycobacterial that can be used on its own

18

what are the toxicities of isoniazid

neurotoxicity - can prevent with B6
hepatotoxicity

19

what is the mechanism of resistance of isoniazid

mutations that lead to underexpression of KatG

20

how can you decrease the neurotoxicity of isoniazid

give em B6

21

what is the MOA of pyrazinamde

unknown

22

what is the cxl use of pyrazinamide

M Tb

23

what are the a/se of pyrazinamde

hyperuricemia
hepatotoxcity

24

what is the MOA of ethambutol

decreases carbohydrate polymerization of mycobacterium cell wall by blocking arabinosyltransferase

25

what is cilinical sue of ethambutol

m TB and with azithromycin/clarithromycin for MAC (Can add rifabutin or ciprofloxacin)

26

a/se of ethambutol please

optic neurpathy - red gree colour blindness

27

what is the MOA of amphotericin B

binds ergosterol to form membrane pores that allow electrolytes through

28

clinical use of amphotericin B

serious systemic mycoses

29

treat Cryptococcus meningitis!

amphotericin B and flucytosine

30

treat systemic blastomyces, cocciodies, histoplasma, candida please

amphotericin B