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Flashcards in Autonomics Deck (69):
1

list autonomic recepors on the eye and agonist effects

alpha 1 - pupillary dilator - mydriasis
alpha2 - decreases aqueous production
beta2 - increases aqueous production, ciliary muscle relaxation
M3 - ciliary muscle contraction - accommodation
M3 - pupillary sphincter - miosis

2

list recetpors on the vasculator and agonist effects

alpha 1 - vasoconstriction
beta 2 - vasodilation
D1 - renal relaxation
H1 - increased permeability -- Gq
V1 - vasodilation
smooth muscle relaxation @ Gs
smooth muscle constriction @ Gq

3

list receptors on the heart and agonist effects

beta1 - heart rate and contractility increase
M2 - heart rate decrease, decreased atrial contractility decrease

4

hemicholium

prevents choline uptake

5

vesamicol

prevents Ach fom getting in the vesicles
(reserpine)

6

botulinum

prevents Ach from bein released.

7

metyrosine

tyrosine hydroxylase BH4
no DOPA is made

8

reserpine

prevents dopamine from getting in to vesicles
(vesamicol)

9

bretylium
guanethidine

prevents release of Ne

10

ATII receptor

promotes vesicular release of NE

11

bethanechol

direct cholinergic
postop ileus, neurogenic ileus, urinary retention

12

carbachol

direct cholinergic
decreases IOP in glaucoma

13

methacholine

direct cholinergic
challenge test for diagnosis of asthma

14

pilocarpine

stimulates tears, sweat, saliva
open angle: ciliary
closed angle: sphincter

15

donepezil
galantamine
rivastigmine

Alzheimer disease
indirect choli agonist

16

Alzheimer disease

donepezil
galantamine
rivastigmine

17

edrophonium

historically dx of MG
indirect choil agonist

18

neostigmine

MG
post op and neurogenic ileus
urinary retension
reversal of NMH blockade post op

19

urinary retention
postp op ileus
neurogenic ileus

bethanachol
neostigmine

20

reversal of NMJ blockade post op

neostigimine

21

physostigmine

anticholinergic (atropine) toxicity
crosses CNS

22

pyridostigmine

MA
long acting
no CNS

23

farmer with organophosphate poisoning

irreversible AChase inhibitor --> CHOLINGERIC SYMPTOMS

DUMBBEELSS: diarrhoea, urination, miosis, bronchospasm, bradycardia, excitement of PNS and CNS, lacrimation, salivation, sweating

treat with atropine (competitive - no effect centrall or at skeletal muscle - nicotinic receptors) or pralidoxime (if early)

24

atropine
homatropine
tropicamide

muscarinic antags
ophthalmic procedures and bradycardia
mydriasis
cycloplegia

25

benztropine

muscarinic antags
CNA - for Parkinson disease and acute dystonia

26

glycopyrrolate IV

muscarinic antags
preop to decrease respiratory decrtions

27

glycopyrrolate oral

muscarinic antags
drooling
peptic ulcer

28

hyoscyamine
dicyclomine

muscarinic antags
antispasmodics for irritable bowel syndrome

29

ipratropium
tiotropium

muscarinic antags
COPD
asthma

30

oxybutynin
solifenacin
tolterodine

GUT muscarinic antags
reduce blader spasms
urge urinary incontinence
overactive bladder

31

scopolamine

muscarinic antags
motion sickness

32

Symptoms that make you think you need to use physostigmine to reverse it all

increasd body temperature - decreasd sweating
rapid pulse
dry mouth
dry flushed skin
cycloplegia
constipation
disorientiation
ATROPINE TOXICITY: hot as a hare, dry as a boen, red as a bet, blind as aboat, man as a hatter

33

jimson week

datura
gardeners pupil - mydriasis due to plant alkaloids

34

tetradotoxin

prevents depol without changing RMP
nausea
diarrhoea
paresthesias
weakness
dizziness
loss of reflexes

35

puffer fish

tetradotoxin

36

ciguatoxin sxs

opens na channels
confuse with cholinergic poisoning
temperature related dysesthesia

37

barracuda snapper moray eel

reed fish
ciguatoxin

38

scrombroid toxin

burning of mouth
flush face
erythema
urticarial
pruritus
headache
may be anaphylaxis like: bronchospasm, angioedema, hypotension
HISTAMINE from FISH

39

bonito mackerel mahi mahi tuna kept at warm tempaerautes

scrombroid

40

albuterol

b2>b1
asthma

41

salmeterol

b2>b1
COPD

42

dobutamine

B1>B2, alpha
heart failure: inotropic>chronotropic
cardiac stress testing

43

dopamine

D1=D2>b>a
unstable bradycardia
heart failure: inotropic AND chronotropic
shock
high doses - alpha effect

44

ephinephrine

b>a
anaphylaxis
asthma
open angle glaucoma (cilairy muscle)
strong at b2 than NE

45

isoproterenol

b1=b2
electrophysiologic evaluation fo tachyarrhythmias
can worsen iscahemia

46

norepinephrine

a1>a2>b
hypotension - but decreases renal perfusion
weaker at B2 than epi

47

phenylephrine

a1>a2
hypotension
ocular procedures - dilator
rhinitis - vasoconstriction

48

amphetamine

indirect feneral agonist
reuptake inhibitor
release stored catecholamines

49

narcolepsy, obesity and ADHD

amphetamine

50

cocaine

indirect general agonist
reuptake inhibitor

avoid beta blockers in cocaine users
vasoconstriction and generalized anesthesia

51

ephedrine

indirect general agonist
release stored catecholamines

52

nasal decongestion
urinary incontinence
hypoteion

ephedrine

53

urinary incontinence vrs urinary retention tx

ephedrine - a1>a2 stim --> incontinence
neostigmine - cholinergic stim --> retention
bethanochol- cholinergic stim --> retention

54

clonidine

alpha 2 agonist
hypertensive urgency
ADHD
Tourette dynfrome

55

tourteet syndrome and ADHD

clonidine

56

hypertension in pregos

alpha-methyldopa
alpha 2 agonist

57

phenozybenzamine

non selective irreversible alpha blocker
post op pheochromocytoma removal

will case orthostatic hypotension and reflex tachycardia

58

phentolamine

non selective reversible alpha blocker
give to ppl on MAOi who eat tyramine containing foods

will cause orthostatic hypotension and reflex tachycardia

59

prazosin, terazosin, doxazosin, tamsulosin

alpha 1 selective inhibis
urinary symptoms of BPH
PTSD (prazosin)
hypertension (all but tamsulosin)

will cause first dose orthostatic hypotension, dizziness, headache

60

mirtazapine

alpha2 selective inhibis
depression

a/se: sedation, increased serum cholesterol and increased appetite

61

PTSD treatment

prazosin
alpha 1 selective inhibitor

62

list the b1> b2 blockers

A-M
acebutolol - partial
atenolol
betaxolol
esmolol
metoprolol

63

list the non selective b blockers

N-Z
nadolol
pindolol - partial
propranolol
timolol

64

non selective alpha and beta blocker please

carvedilol
labetalol
DO NOT END in ''OLOL''

65

selective b1 blocker and b3 agonist and who cares?

nebivolol
cardiac inhibi and activation of NO synthase in vasculature

66

what does b3 do?

agonistm - sitmulates NO synthase

67

bb used for post MI

metoprolol
carvedilol
bisoprolol

68

SVT bb used?

metoprolol
esmolol
class II anti arrhythmics

69

glaucoma and bb?

decreases secretion of aqueous humor
@ B2