Autonomics Flashcards Preview

Pharmocology - step > Autonomics > Flashcards

Flashcards in Autonomics Deck (69)
Loading flashcards...
1

list autonomic recepors on the eye and agonist effects

alpha 1 - pupillary dilator - mydriasis
alpha2 - decreases aqueous production
beta2 - increases aqueous production, ciliary muscle relaxation
M3 - ciliary muscle contraction - accommodation
M3 - pupillary sphincter - miosis

2

list recetpors on the vasculator and agonist effects

alpha 1 - vasoconstriction
beta 2 - vasodilation
D1 - renal relaxation
H1 - increased permeability -- Gq
V1 - vasodilation
smooth muscle relaxation @ Gs
smooth muscle constriction @ Gq

3

list receptors on the heart and agonist effects

beta1 - heart rate and contractility increase
M2 - heart rate decrease, decreased atrial contractility decrease

4

hemicholium

prevents choline uptake

5

vesamicol

prevents Ach fom getting in the vesicles
(reserpine)

6

botulinum

prevents Ach from bein released.

7

metyrosine

tyrosine hydroxylase BH4
no DOPA is made

8

reserpine

prevents dopamine from getting in to vesicles
(vesamicol)

9

bretylium
guanethidine

prevents release of Ne

10

ATII receptor

promotes vesicular release of NE

11

bethanechol

direct cholinergic
postop ileus, neurogenic ileus, urinary retention

12

carbachol

direct cholinergic
decreases IOP in glaucoma

13

methacholine

direct cholinergic
challenge test for diagnosis of asthma

14

pilocarpine

stimulates tears, sweat, saliva
open angle: ciliary
closed angle: sphincter

15

donepezil
galantamine
rivastigmine

Alzheimer disease
indirect choli agonist

16

Alzheimer disease

donepezil
galantamine
rivastigmine

17

edrophonium

historically dx of MG
indirect choil agonist

18

neostigmine

MG
post op and neurogenic ileus
urinary retension
reversal of NMH blockade post op

19

urinary retention
postp op ileus
neurogenic ileus

bethanachol
neostigmine

20

reversal of NMJ blockade post op

neostigimine

21

physostigmine

anticholinergic (atropine) toxicity
crosses CNS

22

pyridostigmine

MA
long acting
no CNS

23

farmer with organophosphate poisoning

irreversible AChase inhibitor --> CHOLINGERIC SYMPTOMS

DUMBBEELSS: diarrhoea, urination, miosis, bronchospasm, bradycardia, excitement of PNS and CNS, lacrimation, salivation, sweating

treat with atropine (competitive - no effect centrall or at skeletal muscle - nicotinic receptors) or pralidoxime (if early)

24

atropine
homatropine
tropicamide

muscarinic antags
ophthalmic procedures and bradycardia
mydriasis
cycloplegia

25

benztropine

muscarinic antags
CNA - for Parkinson disease and acute dystonia

26

glycopyrrolate IV

muscarinic antags
preop to decrease respiratory decrtions

27

glycopyrrolate oral

muscarinic antags
drooling
peptic ulcer

28

hyoscyamine
dicyclomine

muscarinic antags
antispasmodics for irritable bowel syndrome

29

ipratropium
tiotropium

muscarinic antags
COPD
asthma

30

oxybutynin
solifenacin
tolterodine

GUT muscarinic antags
reduce blader spasms
urge urinary incontinence
overactive bladder