Flashcards in Autonomics Deck (69)
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1
list autonomic recepors on the eye and agonist effects
alpha 1 - pupillary dilator - mydriasis
alpha2 - decreases aqueous production
beta2 - increases aqueous production, ciliary muscle relaxation
M3 - ciliary muscle contraction - accommodation
M3 - pupillary sphincter - miosis
2
list recetpors on the vasculator and agonist effects
alpha 1 - vasoconstriction
beta 2 - vasodilation
D1 - renal relaxation
H1 - increased permeability -- Gq
V1 - vasodilation
smooth muscle relaxation @ Gs
smooth muscle constriction @ Gq
3
list receptors on the heart and agonist effects
beta1 - heart rate and contractility increase
M2 - heart rate decrease, decreased atrial contractility decrease
4
hemicholium
prevents choline uptake
5
vesamicol
prevents Ach fom getting in the vesicles
(reserpine)
6
botulinum
prevents Ach from bein released.
7
metyrosine
tyrosine hydroxylase BH4
no DOPA is made
8
reserpine
prevents dopamine from getting in to vesicles
(vesamicol)
9
bretylium
guanethidine
prevents release of Ne
10
ATII receptor
promotes vesicular release of NE
11
bethanechol
direct cholinergic
postop ileus, neurogenic ileus, urinary retention
12
carbachol
direct cholinergic
decreases IOP in glaucoma
13
methacholine
direct cholinergic
challenge test for diagnosis of asthma
14
pilocarpine
stimulates tears, sweat, saliva
open angle: ciliary
closed angle: sphincter
15
donepezil
galantamine
rivastigmine
Alzheimer disease
indirect choli agonist
16
Alzheimer disease
donepezil
galantamine
rivastigmine
17
edrophonium
historically dx of MG
indirect choil agonist
18
neostigmine
MG
post op and neurogenic ileus
urinary retension
reversal of NMH blockade post op
19
urinary retention
postp op ileus
neurogenic ileus
bethanachol
neostigmine
20
reversal of NMJ blockade post op
neostigimine
21
physostigmine
anticholinergic (atropine) toxicity
crosses CNS
22
pyridostigmine
MA
long acting
no CNS
23
farmer with organophosphate poisoning
irreversible AChase inhibitor --> CHOLINGERIC SYMPTOMS
DUMBBEELSS: diarrhoea, urination, miosis, bronchospasm, bradycardia, excitement of PNS and CNS, lacrimation, salivation, sweating
treat with atropine (competitive - no effect centrall or at skeletal muscle - nicotinic receptors) or pralidoxime (if early)
24
atropine
homatropine
tropicamide
muscarinic antags
ophthalmic procedures and bradycardia
mydriasis
cycloplegia
25
benztropine
muscarinic antags
CNA - for Parkinson disease and acute dystonia
26
glycopyrrolate IV
muscarinic antags
preop to decrease respiratory decrtions
27
glycopyrrolate oral
muscarinic antags
drooling
peptic ulcer
28
hyoscyamine
dicyclomine
muscarinic antags
antispasmodics for irritable bowel syndrome
29
ipratropium
tiotropium
muscarinic antags
COPD
asthma
30
