Drug toxicity and a/se Flashcards Preview

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Flashcards in Drug toxicity and a/se Deck (45):
1

coronary vasospasm

cocain, suatriptan, ergot alkaloids

2

cutaneous flushing

vancomycin, adenosime, niacin, CCB

3

dilated cardiomyopathy

doxorubicin, daunorubicin

4

torsades de poitnes

class III, class Ia, macrolide antibiotics, antipsychotics, TCAs

5

adrenocortical insufficiency

secondary to glucocorticoid withdrawl

6

hot flashes

tamoxifen, clomiphene

7

hyperglycemia

tacrolimus, protease inhibitors, niacin MCTZ, coricosteroids

8

hypthyroidism

lithium, amiodarne, sulfonamides

9

acute cholestatic hepatitis jaundice

erythromycin

10

diarrhoea

metforim, erythromycin, colchicine, orlistate, acarbose

11

focal to massive hepatic necrosis

halothane, amanita phalloides, acetaminophen, calporic acid

12

hepatitis

rifampin, isoniazind, pyrazinamide, statins, fibrates

13

pancreatitis

alcohol, azathioprine, didanosine, corticosteroids, valproic acid, furosemide, HCTZ

14

agranulocytosis

ganciclovir, clozapine, colchicine, carbamazepine, methimazole, propylthiouracil

15

aplastic anaemia

benzene, NSAIDs, chloramphenicol, carbamazepine, methimazole, propylthiouracil

16

direct coombs positive anaemia

methyldopa, penicillin

17

gray baby syndrome

chloramphenicol

18

hemolysis in G6PD deficiency

isoniazid, sulfonamides, dapson, primaquine, aspirin, ibuprofen, bitrfurantoin

19

megaloblastic anaemia

phenytoin, methotrexate, sulfa drugs

20

thrombocytopenia

heparin

21

thrombotic complicatiosn

OCP, HRT

22

fat redistribution

protease inhibitiors, corticosteroids

23

gingival hyperplasi

phenytoin, CCB, cyclosporine

24

hypuricemia

thiazides, furosemide, pyrazinamide, niacin, cyclosporine

25

myopathy

colchicine, fibrates, glucocorticoids ,hydroxychloroquine, IFNa, niacin, penicillamine, statins

26

osteoporosis

corticosteroids, heparin

27

photosensitivity

seulfonamides, amiodarone, tetracyclines, 5-FU

28

steven-johnson syndrome

antiepileptic, allopurinol, sulfa, penicillin

29

SLE-like syndrome

sulfa drugs, hydralazine, isoniazis, procainamide, phenytoin, etanercept

30

teeth discolouration

tetracyclines

31

tendonitis, tendon reupture, cartilage damage

fluoroquinolones

32

cinchonism

quinidine, quinine

33

Parkinson-like syndrome

antipsychotics, reserpine, metoclopramide

34

seizures

isoniazid/vit B6 def, bupropion, imipenum/cilastatin, enflurane

35

tardive dyskinesia

antipsychotics, metoclopramide

36

diabetes insipidus

lithium, demeclocycline

37

fanconi syndrome

expired tetracycline

38

hemorrhagic cystistis

cyclophosphamide, ifosfamide

39

interstitial nephritis

methicillin, NSAIs, furosemide

40

SIADH

carbamazepine, cyclophosphamide, SSRIs

41

dry cough

ACE inhibitors

42

pulmonary fiboriss

bleomycin, busulfan, amiodarone, methotrexate

43

antimuscarinic

atropine, TCA, antipsychoitcs, H1 blockers

44

disulfiram like reactin

my cereal goes snap pop: metronisazole, cephalosporins, grisefulvin, procarbazine, fist gen sulfonylureas

45

nephrotoxicity, ototoxicity

aminoglycosides, vancomycin, loops, cisplastin (may respond to amifostine)