Drug toxicity and a/se

Question 1

coronary vasospasm

Answer 1

cocain, suatriptan, ergot alkaloids

Question 2

cutaneous flushing

Answer 2

vancomycin, adenosime, niacin, CCB

Question 3

dilated cardiomyopathy

Answer 3

doxorubicin, daunorubicin

Question 4

torsades de poitnes

Answer 4

class III, class Ia, macrolide antibiotics, antipsychotics, TCAs

Question 5

adrenocortical insufficiency

Answer 5

secondary to glucocorticoid withdrawl

Question 6

hot flashes

Answer 6

tamoxifen, clomiphene

Question 7

hyperglycemia

Answer 7

tacrolimus, protease inhibitors, niacin MCTZ, coricosteroids

Question 8

hypthyroidism

Answer 8

lithium, amiodarne, sulfonamides

Question 9

acute cholestatic hepatitis jaundice

Answer 9

erythromycin

Question 10

diarrhoea

Answer 10

metforim, erythromycin, colchicine, orlistate, acarbose

Question 11

focal to massive hepatic necrosis

Answer 11

halothane, amanita phalloides, acetaminophen, calporic acid

Question 12

hepatitis

Answer 12

rifampin, isoniazind, pyrazinamide, statins, fibrates

Question 13

pancreatitis

Answer 13

alcohol, azathioprine, didanosine, corticosteroids, valproic acid, furosemide, HCTZ

Question 14

agranulocytosis

Answer 14

ganciclovir, clozapine, colchicine, carbamazepine, methimazole, propylthiouracil

Question 15

aplastic anaemia

Answer 15

benzene, NSAIDs, chloramphenicol, carbamazepine, methimazole, propylthiouracil

Question 16

direct coombs positive anaemia

Answer 16

methyldopa, penicillin

Question 17

gray baby syndrome

Answer 17

chloramphenicol

Question 18

hemolysis in G6PD deficiency

Answer 18

isoniazid, sulfonamides, dapson, primaquine, aspirin, ibuprofen, bitrfurantoin

Question 19

megaloblastic anaemia

Answer 19

phenytoin, methotrexate, sulfa drugs

Question 20

thrombocytopenia

Answer 20

heparin

Question 21

thrombotic complicatiosn

Answer 21

OCP, HRT

Question 22

fat redistribution

Answer 22

protease inhibitiors, corticosteroids

Question 23

gingival hyperplasi

Answer 23

phenytoin, CCB, cyclosporine

Question 24

hypuricemia

Answer 24

thiazides, furosemide, pyrazinamide, niacin, cyclosporine

Question 25

myopathy

Answer 25

colchicine, fibrates, glucocorticoids ,hydroxychloroquine, IFNa, niacin, penicillamine, statins

Question 26

osteoporosis

Answer 26

corticosteroids, heparin

Question 27

photosensitivity

Answer 27

seulfonamides, amiodarone, tetracyclines, 5-FU

Question 28

steven-johnson syndrome

Answer 28

antiepileptic, allopurinol, sulfa, penicillin

Question 29

SLE-like syndrome

Answer 29

sulfa drugs, hydralazine, isoniazis, procainamide, phenytoin, etanercept

Question 30

teeth discolouration

Answer 30

tetracyclines

Question 31

tendonitis, tendon reupture, cartilage damage

Answer 31

fluoroquinolones

Question 32

cinchonism

Answer 32

quinidine, quinine

Question 33

Parkinson-like syndrome

Answer 33

antipsychotics, reserpine, metoclopramide

Question 34

seizures

Answer 34

isoniazid/vit B6 def, bupropion, imipenum/cilastatin, enflurane

Question 35

tardive dyskinesia

Answer 35

antipsychotics, metoclopramide

Question 36

diabetes insipidus

Answer 36

lithium, demeclocycline

Question 37

fanconi syndrome

Answer 37

expired tetracycline

Question 38

hemorrhagic cystistis

Answer 38

cyclophosphamide, ifosfamide

Question 39

interstitial nephritis

Answer 39

methicillin, NSAIs, furosemide

Question 40

SIADH

Answer 40

carbamazepine, cyclophosphamide, SSRIs

Question 41

dry cough

Answer 41

ACE inhibitors

Question 42

pulmonary fiboriss

Answer 42

bleomycin, busulfan, amiodarone, methotrexate

Question 43

antimuscarinic

Answer 43

atropine, TCA, antipsychoitcs, H1 blockers

Question 44

disulfiram like reactin

Answer 44

my cereal goes snap pop: metronisazole, cephalosporins, grisefulvin, procarbazine, fist gen sulfonylureas

Question 45

nephrotoxicity, ototoxicity

Answer 45

aminoglycosides, vancomycin, loops, cisplastin (may respond to amifostine)