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Flashcards in Git drugs Deck (60)
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1

name the H2 blockers and which ones you'd prefer to use please

cimetidine
ranitodine
famotidine - preferred
nizatidine - preferred

2

MOA of H2 blockers

bock H2 receptor - decreased gastric acid secretion via blocking increased cAMP in parietal cells

3

uses of H2 blockers

PUD
mild gastric reflux
gastritis

4

toxocitiy of H2 blockers

cimietidine:
inhibits P450 - multiple drug interatcions
anti-androgenic - prolactin release, impotence, decreased libido in men, gynecomastia
cross BBB - dizziness, confusion, headaches
cimetidine and ranitodine:
decrease renal secretion of creatinine

5

list the PPIs please

omeprazole
lansoprazole
esomeprazole
pantprazole
dexlansoprazole

6

what is the MOA of PPIs

IRREVERSIBLE inhibit HKATPase in stomach pariental cells

7

used of PPi

PUD
esophageal reflux
gastriris
Zollinger Ellison syndrome

8

toxos of PPIs

increased risk of C difficile infections
pneumonia
decreased serum Mg with long term use (hypomagnesemia = tetany, hypokalemia, torsasdes de pointes)

9

MOA fo bismuth and sucralfate

bind to ulcer base - protection and establishemt of HCO3 muclsa layer

10

use of bismuth and sucralfate

increased ulcer healing
travelers diarrhoea

11

MOA misoprostal

PGE1 analogue
increase production and secretion of mucosal barrie and decreased acid prodcution

12

uses of misoprostol

prevent NSAID induced PUD
maintain PDA (rubella, TOF, transposition of great vessels and RDS)
off label for induction of labour - ripens cervix

13

toxo of misoprostol

diarrhoea
contraindicated in women of childbearing potential bc abortifacient

14

MOA of ocreotide

long acting somatostatin analogue
inhbits actions of many splanchnic vasocontrsction hormones

15

clinical use of ocreotide

acute variceal bleeds
acromegaly
VIPoma
carcinoid tumours

16

toxo of ocreotide

nausea
cramps
steatorrhoea

17

affects of anatacids

can affect absorption, bioavailability, urinary excretion of toher drugs via alteration of gastric and urinary pH or by delaying gastric emptying

18

list the antacids please

aluminum hydroxide
calcium carbonate
magnesium hydroxide

19

what are s/e of aluminum hydroxide

constipation
proximal muscle weakness
hypokalemia
hypophosphatemia
osteodystrophy
seizures

20

what are s/e of calcium carbonate

hypercalcemia ( stones, bone pain, ab pain, increased urinary frequency, anxiety, altered mental status)
rebound acid production
can chelat and decrease effective ness of drugs ie tetracyclines
hypokalemia

21

what are s/e of magnesium hydroxide

diarrhoea
hyporeflexia
hypotension
hypokalemia
cardiac arrest

22

list the osmotic laxatives please

magnesium hydroxide
magnesium citrate
polyethylene glycol
lactulose

23

moa of osmotic laxatives

provide osmotic load to draw water itno the gi lumen

24

clinical use of osmotic laxatives

constipation

25

use of lactulose and how

hepatic encephaloaty --- makes gut bacteria produces lactic acid and NH4+ is excreted ridding body of NH3

26

toxicity of osmotic laxatives

diarrhoea
dehydration
may be abused by bulimics

27

MOA of sulfasalazine please

sulfapyridine - ab and 5-aminosalicylic acid - antiinflmmatory that is activated by colonic bacteria

28

use of sulfasalazine please

UC and colonic protion of Chrons

29

toxon of suldasalazine

malaise
nausea
sulfonamide toxicity
reversible oligospermia

30

MOA of ondansetron

5HT3 antagonist
decreased vagal simulation
powerful central acting antiemetic