Flashcards in Git drugs Deck (60)
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1
name the H2 blockers and which ones you'd prefer to use please
cimetidine
ranitodine
famotidine - preferred
nizatidine - preferred
2
MOA of H2 blockers
bock H2 receptor - decreased gastric acid secretion via blocking increased cAMP in parietal cells
3
uses of H2 blockers
PUD
mild gastric reflux
gastritis
4
toxocitiy of H2 blockers
cimietidine:
inhibits P450 - multiple drug interatcions
anti-androgenic - prolactin release, impotence, decreased libido in men, gynecomastia
cross BBB - dizziness, confusion, headaches
cimetidine and ranitodine:
decrease renal secretion of creatinine
5
list the PPIs please
omeprazole
lansoprazole
esomeprazole
pantprazole
dexlansoprazole
6
what is the MOA of PPIs
IRREVERSIBLE inhibit HKATPase in stomach pariental cells
7
used of PPi
PUD
esophageal reflux
gastriris
Zollinger Ellison syndrome
8
toxos of PPIs
increased risk of C difficile infections
pneumonia
decreased serum Mg with long term use (hypomagnesemia = tetany, hypokalemia, torsasdes de pointes)
9
MOA fo bismuth and sucralfate
bind to ulcer base - protection and establishemt of HCO3 muclsa layer
10
use of bismuth and sucralfate
increased ulcer healing
travelers diarrhoea
11
MOA misoprostal
PGE1 analogue
increase production and secretion of mucosal barrie and decreased acid prodcution
12
uses of misoprostol
prevent NSAID induced PUD
maintain PDA (rubella, TOF, transposition of great vessels and RDS)
off label for induction of labour - ripens cervix
13
toxo of misoprostol
diarrhoea
contraindicated in women of childbearing potential bc abortifacient
14
MOA of ocreotide
long acting somatostatin analogue
inhbits actions of many splanchnic vasocontrsction hormones
15
clinical use of ocreotide
acute variceal bleeds
acromegaly
VIPoma
carcinoid tumours
16
toxo of ocreotide
nausea
cramps
steatorrhoea
17
affects of anatacids
can affect absorption, bioavailability, urinary excretion of toher drugs via alteration of gastric and urinary pH or by delaying gastric emptying
18
list the antacids please
aluminum hydroxide
calcium carbonate
magnesium hydroxide
19
what are s/e of aluminum hydroxide
constipation
proximal muscle weakness
hypokalemia
hypophosphatemia
osteodystrophy
seizures
20
what are s/e of calcium carbonate
hypercalcemia ( stones, bone pain, ab pain, increased urinary frequency, anxiety, altered mental status)
rebound acid production
can chelat and decrease effective ness of drugs ie tetracyclines
hypokalemia
21
what are s/e of magnesium hydroxide
diarrhoea
hyporeflexia
hypotension
hypokalemia
cardiac arrest
22
list the osmotic laxatives please
magnesium hydroxide
magnesium citrate
polyethylene glycol
lactulose
23
moa of osmotic laxatives
provide osmotic load to draw water itno the gi lumen
24
clinical use of osmotic laxatives
constipation
25
use of lactulose and how
hepatic encephaloaty --- makes gut bacteria produces lactic acid and NH4+ is excreted ridding body of NH3
26
toxicity of osmotic laxatives
diarrhoea
dehydration
may be abused by bulimics
27
MOA of sulfasalazine please
sulfapyridine - ab and 5-aminosalicylic acid - antiinflmmatory that is activated by colonic bacteria
28
use of sulfasalazine please
UC and colonic protion of Chrons
29
toxon of suldasalazine
malaise
nausea
sulfonamide toxicity
reversible oligospermia
30
