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Flashcards in Git drugs Deck (60):
1

name the H2 blockers and which ones you'd prefer to use please

cimetidine
ranitodine
famotidine - preferred
nizatidine - preferred

2

MOA of H2 blockers

bock H2 receptor - decreased gastric acid secretion via blocking increased cAMP in parietal cells

3

uses of H2 blockers

PUD
mild gastric reflux
gastritis

4

toxocitiy of H2 blockers

cimietidine:
inhibits P450 - multiple drug interatcions
anti-androgenic - prolactin release, impotence, decreased libido in men, gynecomastia
cross BBB - dizziness, confusion, headaches
cimetidine and ranitodine:
decrease renal secretion of creatinine

5

list the PPIs please

omeprazole
lansoprazole
esomeprazole
pantprazole
dexlansoprazole

6

what is the MOA of PPIs

IRREVERSIBLE inhibit HKATPase in stomach pariental cells

7

used of PPi

PUD
esophageal reflux
gastriris
Zollinger Ellison syndrome

8

toxos of PPIs

increased risk of C difficile infections
pneumonia
decreased serum Mg with long term use (hypomagnesemia = tetany, hypokalemia, torsasdes de pointes)

9

MOA fo bismuth and sucralfate

bind to ulcer base - protection and establishemt of HCO3 muclsa layer

10

use of bismuth and sucralfate

increased ulcer healing
travelers diarrhoea

11

MOA misoprostal

PGE1 analogue
increase production and secretion of mucosal barrie and decreased acid prodcution

12

uses of misoprostol

prevent NSAID induced PUD
maintain PDA (rubella, TOF, transposition of great vessels and RDS)
off label for induction of labour - ripens cervix

13

toxo of misoprostol

diarrhoea
contraindicated in women of childbearing potential bc abortifacient

14

MOA of ocreotide

long acting somatostatin analogue
inhbits actions of many splanchnic vasocontrsction hormones

15

clinical use of ocreotide

acute variceal bleeds
acromegaly
VIPoma
carcinoid tumours

16

toxo of ocreotide

nausea
cramps
steatorrhoea

17

affects of anatacids

can affect absorption, bioavailability, urinary excretion of toher drugs via alteration of gastric and urinary pH or by delaying gastric emptying

18

list the antacids please

aluminum hydroxide
calcium carbonate
magnesium hydroxide

19

what are s/e of aluminum hydroxide

constipation
proximal muscle weakness
hypokalemia
hypophosphatemia
osteodystrophy
seizures

20

what are s/e of calcium carbonate

hypercalcemia ( stones, bone pain, ab pain, increased urinary frequency, anxiety, altered mental status)
rebound acid production
can chelat and decrease effective ness of drugs ie tetracyclines
hypokalemia

21

what are s/e of magnesium hydroxide

diarrhoea
hyporeflexia
hypotension
hypokalemia
cardiac arrest

22

list the osmotic laxatives please

magnesium hydroxide
magnesium citrate
polyethylene glycol
lactulose

23

moa of osmotic laxatives

provide osmotic load to draw water itno the gi lumen

24

clinical use of osmotic laxatives

constipation

25

use of lactulose and how

hepatic encephaloaty --- makes gut bacteria produces lactic acid and NH4+ is excreted ridding body of NH3

26

toxicity of osmotic laxatives

diarrhoea
dehydration
may be abused by bulimics

27

MOA of sulfasalazine please

sulfapyridine - ab and 5-aminosalicylic acid - antiinflmmatory that is activated by colonic bacteria

28

use of sulfasalazine please

UC and colonic protion of Chrons

29

toxon of suldasalazine

malaise
nausea
sulfonamide toxicity
reversible oligospermia

30

MOA of ondansetron

5HT3 antagonist
decreased vagal simulation
powerful central acting antiemetic

31

use for ondansetron

control post op vomiting and in paitnets undergoing cancer chemotehrapy

32

toxicity of ondansetron

headache
constipation
QT interval prolongation

33

MOA of metoclopramide

D2 receptor antagonist
increase restone tone, contractility LES tone motility
does nto change colon transport time

34

use of metoclopramide

diabetic and postsurgery gastropareies
antiemetic

35

toxo of metoclopramide

parkinsonia effects
tardive dyskinesia
restlessness
drowsiness
fatigue
depression
diarrhoea
drug interaction with digoxin and diabetic agents

36

metoclopramide contra Indi in?

small bowel obstruction
parkinsons

37

MOA of orlistat

inhibits gastric and pancreatic lipase - decreases breakdown and absorption of dietary fats

38

clinical use of orlistat

weight loss

39

a/se of orlistat

steatorrhoea
decreased absorption of fat soluble vitamiens

40

treatmet of PUD

H2 antags
PPI
misoprostal - prevent

41

treatment of gastirtis

H2 antags
PPI

42

treatment of esophageal reflux

PPI
mild - H2 antags

43

treatment of zollinger Ellison syndrome

PPI

44

to promote ulcer healign

bismuth and sucralfate

45

treatment of travellers diarrhoea

bismuch and sucralfate

46

maintain an PDA

misoprostol

47

induced labour
off label

misoprostol

48

acromegaly

octreotide

49

VIPoma

octreotide

50

carcinoid tumours

octreotide

51

acute variceal bleeding

octreotide

52

constipation

magnesium hydroxide
magnesium citrate
polyethylene glycol
lactulose

53

UC and Chronis

sulfasalazine

54

post op vomiting and chemo tx patints

ondansetron

55

diabetic and postop gastropareies

metoclopramide

56

weight loss

orlistat

57

toxicity includes: diarrhoea

misoprostol
magnesium hydroxide
magnesium citrate
lactulose
polyethylene glycol
metoclopramide

58

toxicity includes electrolyte imbalance

PPIs - decreased serum Mg with long term use
aluminum hydroxide - hypokalemia and hypophosphatemia
calcium carbonate - hypercalcemia and hypokalemia
magnesium hydroxide - hypokalemia

59

toxicity includes steathorrhoea

ocreotide
orlistate
OOOOO

60

toxicity includes cardiac thigns

magnesium hydroxide - cardiac arrest
ondansetron - QT prolongation