msk, skin, ct - last one eeekkkk!! Flashcards Preview

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Flashcards in msk, skin, ct - last one eeekkkk!! Deck (61):
1

function fo LTC4 D4 and E4

increases bronchial tone

2

function fo LTB4

PMN chemo

3

function fo PGI2

decrease platelet aggregation
decrease vascular tone

4

function of PGE1

decreas vascular tone

5

function of PGE2

increases uterine tone

6

function fo PGF2

increases uterine tone

7

function of thromboxane A2

increases platelet aggregation
increases vascular tone

8

moa acetaminophen

reversibly inhibits cox, mostly in cns
inactivated peripherally

9

cx use of acetaminophen

antipyretic
analgesic
not anti inflammatory
children with viral infection to avoid reyes syndrome

10

toxo of acetaminophen

o/s = hepatic necrosis and NAPQI uses up all the glutathion and causes toxic tissue byproducts in the liver

11

antidote fo acetaminophene o/d

NAC - regenerates glutathione

12

moa aspirin

irreversibly linhibits cyclooxyngease one and two via acetylation - decrease txa2 and pgs
increase bleeding time (no change to pt and ptt)

13

low dose of aspirin?

<300 = platelet inhibit aggregation
causes secretion fo uric acid

14

intermediate dose of aspirin?

300-2400 = antipyretic and analgesic

15

high does aspirin?

2400-4000 = antiinflammatory
reabsorption of uric acid weakly

16

toxo of aspirin

tinnitus
gi ulceration

17

chornic used of aspirin?

acute renal failure, interstitial nephtiritis, gi bleeding

18

children with aspiring

not in viral infections unless you want to stupor/coma/hepatic encephalopathy them up

19

acid base balance with aspring

first - respiratory alkalaosis
progresses - mixed metabolic acidodid resp alkalaossi
used the formulat to see if compensated....somethting liek 1.5 HCO3 + /-??? LOOK UP BAH darn.

20

moa celecoxib

reversibly inhibits COS2

21

where is cox 2 found

inflammatory cells
vascular endothelium
mediates inflammation and pian

22

what does cox1 do?

helps maintain gastric mucosa

23

benefit of celecoxib

no corrosive effet like other nsaids on the gi liking
spared paltelet function as txa2 is dependent on COX1

24

clinical use fo celecoxib

RA and OA

25

treat RA and OA

celecoxib

26

toxo of celecoxib

sulfa
thrombotic event risk increase

27

list the nsaids

ibuprofen
naproxen
diclofenace
indomethacin
ketorolac

28

moa of nsaids

reversibly inhibit cox 1 and 2. block pg synthesis

29

use of msaids

antipyretic, analgesic, antiinflammatory

30

what is indomethacin used for

closign a pda

31

a/se of nsaids please

interstitial nephritis
gastric ulcer
renal iscehmia - pgs vasodilate afferent arteriole

32

what are bisphosphonates

DRONTES
alendronate

33

moa of dronates

bisphosphonates
pyrophosphate analougs that bind hydroxyapatite in bone and inhibit osteoclast activity

34

use of dronates

osteoporposis
hypercalcemia
paget disease of bone

35

treat hypercalcemia

dronate/bisphosphonates

36

treat pagets disease

dronates

37

what is teriparatide

recombinant PTH analog given subcutaneously daily
icnreased osteoblastic activity

38

use of teriparatide

osteoproosis - causes increased boen growth vrs antiresorptive threaphy cough cough bisphosphonates

39

toxo of teriparatide

transient hypercalcemia
increased risk of osteosarcomas (seen in rodents)

40

drug associated potentially with icnreased risk of osteosarcoma?

teriparatide

41

list the drugs used for chronic gout as preventative tx

allopurinol
febuxostat
pegloticase
probenecid

42

moa fo allopurinol

inhibites xanthine oxisase after being converted to alloxanthing
decrease conversion fo xanthine to uric acid

43

cxl use of allopurinol outside of preventative in chronci gout

luekemia and lymphoma to prevent tumor lysis associated urate neprhotpahty

44

what drugs shoudl be of concern when treating simultaenously with allopurinol

azothioprine and 6 MP = will be icnreased bc both are normally metabolized by xanthine oxidase

45

what is febuxostat

inhibits xanthine oxidase
preventative gout

46

what is pegloticase

recombinant uricase that catalyzes metabolism or uric acid to allantoin - more water soluble

47

what is probenecid

inhibits reabsorption of uric acid in proximal covoluted tublue - also inhibtis secretino of penicillin

48

a/se of probenecid

can ppt uric acid calculi

49

tx for acute gout pelase list all

nsaids, glucocorticoids and colchicine

50

which nsaids are use for acute gout

naproxen
indomethacin

51

how are glucocorticoids used for acute gout

oral or intra-articular

52

what is colchicine?

binds and stablized tubulin to inhibit mt polymerization impairing PMN chemotaxis and degranulation

53

a/se of colchicine

gi side effects

54

use of colchicine

acute and prophylactic gout

55

what drugs should be avoided in gout treatmetn?

salicylates - all but the highest doses depress uric acid clearance so even high doese have only minor uricosuric acitivy

56

what are a/se of TNFa inhibitos

predispose to infection includign reactivation of latent TB

57

why do you have to worry abotu TB with TNFa inhibitors

bc TNFa promotes granuloma formation and stabilization

58

what is etaneracept

TNFa IgG1 Fc fusion protein made by recombinat DNA
aka decoy receptor for TNFa

59

what do you use etaneracept for

RA, ankylosing, psoriais

60

what are infliximab and adalimumab?

anti TNFA monoclona abts

61

uses of infliximab abd adalimumab

the seronegs and RA instead of reactive/reiters
IBD, psoriasis, ankylosing,