Flashcards in msk, skin, ct - last one eeekkkk!! Deck (61)
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1
function fo LTC4 D4 and E4
increases bronchial tone
2
function fo LTB4
PMN chemo
3
function fo PGI2
decrease platelet aggregation
decrease vascular tone
4
function of PGE1
decreas vascular tone
5
function of PGE2
increases uterine tone
6
function fo PGF2
increases uterine tone
7
function of thromboxane A2
increases platelet aggregation
increases vascular tone
8
moa acetaminophen
reversibly inhibits cox, mostly in cns
inactivated peripherally
9
cx use of acetaminophen
antipyretic
analgesic
not anti inflammatory
children with viral infection to avoid reyes syndrome
10
toxo of acetaminophen
o/s = hepatic necrosis and NAPQI uses up all the glutathion and causes toxic tissue byproducts in the liver
11
antidote fo acetaminophene o/d
NAC - regenerates glutathione
12
moa aspirin
irreversibly linhibits cyclooxyngease one and two via acetylation - decrease txa2 and pgs
increase bleeding time (no change to pt and ptt)
13
low dose of aspirin?
<300 = platelet inhibit aggregation
causes secretion fo uric acid
14
intermediate dose of aspirin?
300-2400 = antipyretic and analgesic
15
high does aspirin?
2400-4000 = antiinflammatory
reabsorption of uric acid weakly
16
toxo of aspirin
tinnitus
gi ulceration
17
chornic used of aspirin?
acute renal failure, interstitial nephtiritis, gi bleeding
18
children with aspiring
not in viral infections unless you want to stupor/coma/hepatic encephalopathy them up
19
acid base balance with aspring
first - respiratory alkalaosis
progresses - mixed metabolic acidodid resp alkalaossi
used the formulat to see if compensated....somethting liek 1.5 HCO3 + /-??? LOOK UP BAH darn.
20
moa celecoxib
reversibly inhibits COS2
21
where is cox 2 found
inflammatory cells
vascular endothelium
mediates inflammation and pian
22
what does cox1 do?
helps maintain gastric mucosa
23
benefit of celecoxib
no corrosive effet like other nsaids on the gi liking
spared paltelet function as txa2 is dependent on COX1
24
clinical use fo celecoxib
RA and OA
25
treat RA and OA
celecoxib
26
toxo of celecoxib
sulfa
thrombotic event risk increase
27
list the nsaids
ibuprofen
naproxen
diclofenace
indomethacin
ketorolac
28
moa of nsaids
reversibly inhibit cox 1 and 2. block pg synthesis
29
use of msaids
antipyretic, analgesic, antiinflammatory
30
