msk, skin, ct - last one eeekkkk!! Flashcards Preview

Pharmocology - step > msk, skin, ct - last one eeekkkk!! > Flashcards

Flashcards in msk, skin, ct - last one eeekkkk!! Deck (61)
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1

function fo LTC4 D4 and E4

increases bronchial tone

2

function fo LTB4

PMN chemo

3

function fo PGI2

decrease platelet aggregation
decrease vascular tone

4

function of PGE1

decreas vascular tone

5

function of PGE2

increases uterine tone

6

function fo PGF2

increases uterine tone

7

function of thromboxane A2

increases platelet aggregation
increases vascular tone

8

moa acetaminophen

reversibly inhibits cox, mostly in cns
inactivated peripherally

9

cx use of acetaminophen

antipyretic
analgesic
not anti inflammatory
children with viral infection to avoid reyes syndrome

10

toxo of acetaminophen

o/s = hepatic necrosis and NAPQI uses up all the glutathion and causes toxic tissue byproducts in the liver

11

antidote fo acetaminophene o/d

NAC - regenerates glutathione

12

moa aspirin

irreversibly linhibits cyclooxyngease one and two via acetylation - decrease txa2 and pgs
increase bleeding time (no change to pt and ptt)

13

low dose of aspirin?

<300 = platelet inhibit aggregation
causes secretion fo uric acid

14

intermediate dose of aspirin?

300-2400 = antipyretic and analgesic

15

high does aspirin?

2400-4000 = antiinflammatory
reabsorption of uric acid weakly

16

toxo of aspirin

tinnitus
gi ulceration

17

chornic used of aspirin?

acute renal failure, interstitial nephtiritis, gi bleeding

18

children with aspiring

not in viral infections unless you want to stupor/coma/hepatic encephalopathy them up

19

acid base balance with aspring

first - respiratory alkalaosis
progresses - mixed metabolic acidodid resp alkalaossi
used the formulat to see if compensated....somethting liek 1.5 HCO3 + /-??? LOOK UP BAH darn.

20

moa celecoxib

reversibly inhibits COS2

21

where is cox 2 found

inflammatory cells
vascular endothelium
mediates inflammation and pian

22

what does cox1 do?

helps maintain gastric mucosa

23

benefit of celecoxib

no corrosive effet like other nsaids on the gi liking
spared paltelet function as txa2 is dependent on COX1

24

clinical use fo celecoxib

RA and OA

25

treat RA and OA

celecoxib

26

toxo of celecoxib

sulfa
thrombotic event risk increase

27

list the nsaids

ibuprofen
naproxen
diclofenace
indomethacin
ketorolac

28

moa of nsaids

reversibly inhibit cox 1 and 2. block pg synthesis

29

use of msaids

antipyretic, analgesic, antiinflammatory

30

what is indomethacin used for

closign a pda