Antidepressants Flashcards Preview

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Flashcards in Antidepressants Deck (19):
0

tranylcypromine

MAOI
- irreversible and non-selective inhibit action of a and b MAO
- used when the patient doesn't to respond to other treatments - atypical depression


Others: isocarboxazid, phenelzine

1

Bupropion

Atypical antidepressant - NDRI
Causes release of NE and kinda dopamine and inhibits dopamine and NE reuptake
Resembles amphetamine

Use: depression atypical
Adjunct in smoking cessation
ADHD

2

Selegiline,

MAOI

Mao b at normal doses
- irreversible inhibition of MAO A and B at high concentrations

Uses : depression and adjunct in Parkinson's

3

Amitriptyline

Tricyclic antidepressant
MOA: inhibition of NE and 5-HT reuptake

Not commonly used because of adverse effects.
At lower end may be used for pain and migraine prophylaxis


Others: nortriptyline, imipramine, desipramine, clomipramine

4

Imipramine

Tricyclic antidepressant
MOA: inhibition of NE and 5-HT reuptake

Not commonly used because of adverse effects.
At lower end may be used for pain and migraine prophylaxis
Enuresis

Others: amitriptyline, nortriptyline,desipramine, clomipramine

5

Desipramine

Tricyclic antidepressant
MOA: inhibition of NE and 5-HT reuptake

Not commonly used because of adverse effects.
At lower end may be used for pain and migraine prophylaxis


Others: amitriptyline, nortriptyline,imipramine, clomipramine

6

Fluoxetine

SSRI's
Selective serotonin reuptake blocker

Uses: depression ( typical and melancholic)
Anxiety, OCD ( not citalopram) , panic disorder, PTSD , premenstrual dysphoric disorder


Others: citalopram, sertraline, fluvoxamine, paroxetine

7

clomipramine

Tricyclic antidepressant
MOA: inhibition of NE and 5-HT reuptake

Not commonly used because of adverse effects.
At lower end may be used for pain and migraine prophylaxis
OCD


Others: amitriptyline, nortriptyline,imipramine, desipramine

8

Mirtazapine

5HT2 receptor antagonist
Inhibits autoregulation of NE and 5HT neurons by blocking alpha-2 presynaptic receptors and 5HT2A, 2C and 3 postsynaptically .

Uses: depression ( melancholic)

9

Duloxetine

Inhibition org NE and 5-HT reuptake
SNRI's
⭐️don't bind to histamine, alpha adrenergic and muscarinic receptors so are better tolerated than tricyclics

Uses: atypical depression, anxiety, stress, urinary incontinence, vasomotor symptoms of menopause, pain syndromes

Other : venlafaxine

10

Citalopram

SSRI's
Selective serotonin reuptake blocker

Uses: depression ( typical and melancholic)
Anxiety, OCD ( not citalopram) , panic disorder, PTSD , premenstrual dysphoric disorder


Others: , sertraline, fluoxetine, fluvoxamine, paroxetine

11

Sertraline

SSRI's
Selective serotonin reuptake blocker

Uses: depression ( typical and melancholic)
Anxiety, OCD ( not citalopram) , panic disorder, PTSD , premenstrual dysphoric disorder


Others: citalopram, , fluoxetine, fluvoxamine, paroxetine

12

Venlafaxine

Inhibition org NE and 5-HT reuptake
SNRI's
⭐️don't bind to histamine, alpha adrenergic and muscarinic receptors so are better tolerated than tricyclics

Uses: atypical depression, anxiety, stress, urinary incontinence, vasomotor symptoms of menopause


Other : dullxetine

13

Trazadone

Blocks 5HT reuptake and inhibits 5HT2A receptors postsynaptically

Uses: insomnia

14

Phenelzine

MAOI
- irreversible and non-selective inhibit action of a and b MAO
- used when the patient doesn't to respond to other treatments - atypical depression


Others: isocarboxazid, tranylcypromine

15

Isocarboxazid

MAOI
- irreversible and non-selective inhibit action of a and b MAO
- used when the patient doesn't to respond to other treatments - atypical depression


Others: tranylcypromine, phenelzine

16

Fluvoxamine

SSRI's
Selective serotonin reuptake blocker

Uses: depression ( typical and melancholic)
Anxiety, OCD ( not citalopram) , panic disorder, PTSD , premenstrual dysphoric disorder


Others: citalopram, sertraline, fluoxetine, , paroxetine

17

nortriptyline

Tricyclic antidepressant
MOA: inhibition of NE and 5-HT reuptake

Not commonly used because of adverse effects.
At lower end may be used for pain and migraine prophylaxis


Others: amitriptyline,imipramine, desipramine, clomipramine

18

Paroxetine

SSRI's
Selective serotonin reuptake blocker

Uses: depression ( typical and melancholic)
Anxiety, OCD ( not citalopram) , panic disorder, PTSD , premenstrual dysphoric disorder


Others: citalopram, sertraline, fluoxetine, fluvoxamine