Sex Hormones Flashcards Preview

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Flashcards in Sex Hormones Deck (14):
1

Ethinyl estradiol

Oral contraceptive, hormone replacement therapy, hypogonadism

MOA: Replaces Estrogen

2

Conjugated equine estrogens

Hormone replacement therapy

3

Tansdermal estradiol

Hormone replacement therapy or contraception; Replaces estrogen w/o first pass metabolism

4

Estradiol cypionate and estradiol valerate

Used for IM injections; replaces estrogen w/o first pass metabolism

5

Progestins

MOA: Feedback inhibition prevents ovulation and thickening of cervical mucous, atrophy of endometrium

Hirsutism (less common w/ newer agents), acne, wt gain, possible glucose intolerance, decreased HDL and increases LDL, breakthrough bleeding (progestin only), depression

p450 inducers can enhance elimination, enterohepatic metab interference can enhance elimination

6

Estrogen

Feedback inhibition prevents ovulation

Nausea, breast tenderness, increased skin pigmentation, migraine, inc coagulation, hypertension, breast cancer?, gallstones, elevate serum binding proteins, endometrial hyperplasia/cancer (if used w/o progestin in HRT)

p450 inducers can enhance elimination, enterohepatic metab interference can enhance elimination, increase bound estrogen thyroxine testosterone and iron (due to inc serum binding protein

7

Medroxyprogesterone acetate

used for IM injections (depo-provera); progesterone analogue

8

Medroxyprogesterone

Used in HRT; progesterone analogue

9

Norgestrel and levonorgestrel

Used in combination oral contraceptive, progestin only formulation, levo used for postcoital contraceptive

progesterone analogue, highest androgenic activity

10

Norethindrone

Combination OC, progestin only formulation

progesterone analogue; medium androgenic activity

11

Desogestrel

Combination OC

progesterone analogue; lowest androgenic activity

Not commonly used due to increased DVT risk

12

Drospirenone

Combination OC

progesterone analogue w/ anti-androgenic activity

Spironolactone derivative

Increased blood clots compared to standard contraceptives

13

Ulipristal Acetate

Postcoital contraceptive (effective 5 days after)

Progesterone receptor modulator (similar to RU-486)

14

Absolute contraindications for OC

Breast cancer or estr dependent neoplasia; abnormal genital bleeding; Hx of DVT or PE; Hx CVA or MI; Liver tumor; Heavy smoker after 35 y/o; Less than 6 weeks postpartum and breastfeeding