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Flashcards in Bleeding Disorder - Pharm Deck (10):

Vitamin K

Vitamin K1 - oral and parental forms
- onset of effect is 6 hours
- effect is complete by 24 hours
- IV should be slow bc rapid infusion can cause dyspnea, chest and pain back and death


Aminocaproic acid : MOA , use , SE

MOA: inhibits plasminogen activation
Use: adjective therapy in hemophilia , bleeding from fibrinolytic therapy , prophylaxis for rebleeding from intracranial aneurysms
SE: intravascular thrombosis

don't use in pts with DIC or genitourinary bleeding of the upper tract.


Treatment of mild hemophilia for small bleeds - non blood product

Desmopressin acetate (DDAVP)


Deep cuts or internal bleeding pt with hemophilia will be treated by

Replacing the missing clotting factor


Factors VIII(a) and IX (b)

- derived from heat or detergent treated factor concentrates from large pools of plasma
- prions are not removed
Best to use recombinant clotting factor preps


Recombinant IL- 11 that stimulates bone marrow platelet production

- used for patients with thrombocytopenia or prevention of it
- can causes anemia, fluid in the lungs and transient atrial arrhythmias



Peptibody that contains an MpI binding peptide linked to FCC antibody fragment

- it activated thrombopoietin receptor



Use of romiplastin

Chronic idiopathic thrombocytopenia when a pt does not respond to steroid, Immunoglobulins or splenectomy



Analogue of vasopressin
- increases release of factor VIII and Von willebrand factor from storage sites


Use of Desmopressin

Hemophilia A and vWF disease , used in prep for minor surgery like a tooth extraction

Can be used IV, SC, or intranasally