Hypertension Flashcards Preview

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Flashcards in Hypertension Deck (15):
0

Aliskiren

Renin inhibitor, poor bioavailibilty
Contraindicated with ACEi and ARB in pt with diabetes

1

Captopril

Class 1 ACEi (active prior to metabolism)

2

Losartran

ARB

3

Valsartan

ARB

4

Verapamil and Diltiazam

CCB; - chronotroph, - ionotroph

5

Nifedipine, amlodipine, felodipine

Dihydropyridines

6

CCB Major Indication

Stable angina, Unstable angina (verapamil and diltiazem), hypertension, supraventricular tachycaridia (verapamil and diltiazem)

7

Lisinopril

Class III ACEi: not metabolized and excreted unchanged

8

ACEi indication

Hypertension; CHF; diabetic nephropathy; Post-myocardial infarct; type II diabetes

9

ACEi Adverse Events

Dry cough/Skin Rash; hypotension; hyperkalemia (caution w/ pt. taking K sparing diuretics); acute renal failure due to dec GFR; teratogenesis; angioedema; neutropenia (Captopril); loss of taste (captopril); oral lesions (Captopril)

10

amiloride/triamterene

K sparking diuretic, inhibit ENaC in collecting duct. (weak)

11

Spironolactone/eplerenone

antagonize the effects of aldosterone at collecting duct

12

conivaptan

Aquertic: Mixed V1 V2 antagonist delivered through IV (prevents transfer of aquaporin-2 onto collecting duct) Treatment for hyponatremia

13

Tolivaptan

Aquaertic: oral V2 antagonist: treatment for hyponatremia

14

Minoxidil

K channel opener, Rogaine