Antiviral chemotherapy Flashcards Preview

Pharmacology > Antiviral chemotherapy > Flashcards

Flashcards in Antiviral chemotherapy Deck (10):
1

Amantadine

Influenza A, inhibits M2 proton channel in the viral envelope to prevent uncoating (useful in first 48 h or prophylactically); useful initial therapy for parkinson's disease

2

Rimantadine

Influenza A, inhibits M2 proton channel in the viral envelope to prevent uncoating (useful in first 48 h or prophylactically

3

Zanamivir/Oseltamivir

Influenza A and Influenza B; Inhibits neuramidase; Oseltamivir drug of choice for prevention of bird flu

4

Acyclovir/Valacyclovir/Famciclovir/penciclovir

Herpes virus; phosphorylated thymidine kinase (viral)-substrate inhibitor for DNA polymerase, chain termination; trifluridine for herpes keratitis

5

Ganciclovir

CMV retinitis (IV for acute); same mechanism as acyclovir but more active for CMV; AE: bone marrow suppression, CNS effects; Valganciclovir (oral or occular implant)

6

Foscarnet

Alternative for CMV retinitis; Pohsphonate derivative, inhibits DNA pol. and reverse transcriptase with the pyrophosphate binding site; AE:reduced renal function

7

Cidofovir

CMV retinitis; mimics deoxycytidine monophosphate, must be administered w/ probenecid

8

Ribavirin

Influenza A and B and RSV; Mixed MOA; used orally in combo w/ IFN for Hep C

9

Fomivirsen

CMV retininhibits translation of viral RNA

10

IFN

Hep B and Hep C; protein kinase pohsphorylates and inactivates initiation factors