Cancer Chemotherapy Flashcards Preview

Pharmacology > Cancer Chemotherapy > Flashcards

Flashcards in Cancer Chemotherapy Deck (37):
1

Aldesleukin (IL-2)

Inc. lymphocyte differentiation and inc NKs: renal cell cancer and metastatic melanoma

2

Interleukin-11

Platelet formation

3

Filgrastim (G-CSF)

Granulocyte formation (marrow recovery)

4

Sargramostim (GM-CSF)

Granulocyte and macrophage recovery

5

MOPP

Mechlorethamine- alkylating agent; Oncovin= inhibitor of microtubules; Procarbazine- alkylating agent; Prednisone- apoptosis inducer

6

MOPP Toxicity

Bone marrow suppression, allergic reaction, infertility, high risk of acute leukemia

7

ABVD

Adriamycin-topoisomerase inhibitor; Bleomicin-free radical producer; Vinblastine- microtubule inhibitor; Dacarbazine-alkylating agent

8

ABVD Toxicity

Hair loss, N/V, myelosuppression, neuropathy

9

Tumor Lysis Syndrome

HYPERKALEMIA (cardiac conduction), HYPERPHOSPHOTEMIA (renal precipitates), HYPOCALCEMIA (renal precipitate, tetany, myopathy), Hyperuricemia/uricosuria (acute uric acid nephropathy)

10

antimetabolites (CCS)

Folate antagonists; pyrimidine analogs; Purine analogs: S phase specific

11

Folate antagonists

Methotrexate; Pemetrexed; 5-Fluorouracil; Capecitabine

12

Methotrexate

ALL; breast cancer; AE: reversible suppression of bone marrow (treated with Leucovorin Rescue); MOA: Reduced folate carrier brings it into the cell uses FPGS enzyme to remain in cells

13

Pemetrexed

Lung Cancer; AE: reversible suppression of bone marrow (treated with Leucovorin Rescue MOA: Same as methotrexate but does not use FPGS enzyme

14

5-flourouracil

Carcinomas of GI; breast cancer; AE: coronary atherosclerosis, alopecia, thrombophlebitis MOA: blocks thymidylate synthase (converts dUMP to dTMP)

15

Capecitabine

Metastatic colorectal cancer AE: coronary atherosclerosis, alopecia, thrombophlebitis MOA: blocks thymidylate synthase (converts dUMP to dTMP)

16

Leucovorin Rescue

active form of vitamin D complexed with folate; enters normal cells but not cancer cells. used with MTX

17

Cytarabine (Ara-C)

Pyrimidine analog: liquid tumors; AE myelosuppression

18

6-Mercaptopurine (6-MP)

Purine analog: liquid tumors; AE myelosuppression

19

Alkylating Agents (NCCS)

Nitrogen Mustards: Nitrosoureas: Platinum compounds: Trazenes
Directly modifies DNA double helix (add alkyl group to DNA)

20

Nitrogen Mustard

Cylophosphamide, mechlorethamine, Chlorambucil

21

Cyclophasphamide

NHL, ovarian and breast cancer Must be converted in the liver (p-450) AE: bone marrow suppression and Hemorrhagic cystitis

22

Busulfan

CML AE: pulmonary fibrosis and hyperpigmentation

alkyl sulfonate

23

Chlorambucil

CML AE: bone marrow suppression, hepatotoxicity

24

Nitrosoureas

Brain Tumors (very permeable to BBB); Carmustine, Lomustine, Semustine

25

Nitrogen Mustards and Nitrosoureas toxicity

Hematopoietic (Granulocyte and platelet suppression); GI (n/v); Gonadal damage (disappearance of testicular germ cells-potentially reversible, amenorrhea-irreversible); Alopecia

26

Platinum Compounds

Cisplatinum, carboplatinum, oxaliplatin, tetraplatin
Testicular Cancer, bladder cancer, ovarian cancer
Toxicity Renal (ATN), ototoxicity (tinnitus), GI (severe nausea associated w/ chemo trigger zone)

27

Triazenes

Methylate DNA, Procarbazine, dacarbazine
Hodgkin lymphoma, Brain tumors, melanoma
Toxicity: bone marrow suppression, sterility, immunosuppression

28

Doxorubicin

Topoisomerase II inhibitor, Intercalates in DNA and produces free radicals. (Red Devil)
Hogkin Lymphoma (ABVD), Breast Cancer, Endometrial Cancer, Lung Cancer, Ovarian Cancer
AE: cardiotoxicity

29

Etoposide

Binds topoisomerase II
Lung Cancer, Testicular Cancer, Leukemia
AE: BMS

30

Bleomycin

Antibiotic, Binds DNA and chelates Iron and generates free radicals, works in G2 phase
Hodgkin Lymphoma (ABVD), Testicular Cancer
AE: Pulmonary Fibrosis

31

Prednisone

Triggers apoptosis
CLL, Hodgkin Lymphoma (MOPP)
AE: cushings

32

Plant alkaloids

Vinca alkaloids, Taxanes
Inhibit normal microtubule functioning

33

Vincristin (MOPP) and vinblastin (ABVD)

Blocks polymerization of microtubles, M-phase specific

Hodgkin Lymphoma, Wilms Tumor, Choriocarcinoma, Neuroblastoma
AE: Neurotoxicity, Paralytic ileus, BMS

34

Paclitaxel, Docetaxel

Stabilize tubulin

Ovarian cancer, Local breast cancer (adjuvant), met breast cancer, non-small cell lung, Prostate cancer

35

Tyrosine Kinase inhibitors

Monoclonal antibodies or small molecules

36

Imatinib

BCR-ABL CML, also for gastric carcinoma c-KIT and PDGFR-Alpha

37

Dasatinib

New generation of Imatinib