Prostaglandins And Other Eicosanoids Flashcards Preview

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Flashcards in Prostaglandins And Other Eicosanoids Deck (30):
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LTB4

Chemotactic factor in inflammation

1

LTC4 and LTD4

Bronchoconstrictiors important in anaphylaxis and cause edema

2

Zileuton

Lox inhibitor - blocks synthesis asthma prophylaxis

3

Montelukast zarfirlukast

Leukotriene receptor inhibitors

Blocks CydLT1 receptors reduces bronchoconstriction in asthma

Asthma prophylaxis

4

TXA2

Causes platelet aggregation vasoconstriction

5

Epoprostenol

PGI2 - causes vasodilation and reduces platelet aggregation

Used in pulmonary HTN and anti platelet agent in extra corporeal dialysis

6

Misoprostol

PGE1 caused increased HCO3 and mucus secretion in stomach and uterine contraction

Protective agent in peptic ulcer disease
Abortifacient

7

Alprostadil

Pge1

Injectable form for erectile dysfunction

8

PGE1

Relaxes smooth muscle in ductus arteriosus

Transpositions of great vessels to maintain patent ductus until surgery

9

Dinoprostone

PGE2
Low concentrations contract
Higher ones relax uterine and cervical smooth muscle

Used for abortions and cervical ripening

10

Latanoprost

PGF2

Increases outflow of aqueous humor reduces intraocular pressure

Used in glaucoma

Color change in iris

11

No selective cox1 and cox 2 inhibitors

Ibuprofen, indomethacin , naproxen

Reversibly inhibit both cox

12

Aspirin

Irreversibly inhibit cox 1 and cox 2

13

Celecoxib

Selectively reversibly inhibits cox 2

14

PGI2

Prostacyclin formed by cox2 promotes vasodilation and inhibits platelet aggregation

15

Acetaminophen

MOA: unclear may inhibit a cox3
Has analgesic effects and antipyretic . Lacks anti-inflammatory or anti platelet

16

Ketorolac

Cox 1 selective

IM used for moderate to severe pain since it's equal to morphine
Not an anti inflammatory
Short term use and not before surgery

17

Flurbiprofen

Relatively cox 1 selective

18

Ketoprofen

Non selective

19

Aspirin

Non selective

20

Naproxen

Non selective

21

Ibuprofen

Non selective

22

Indomethacin

Non selective

23

Sulindac

Non selective

24

Celecoxib

Relatively cox 2 selective

25

Rofecoxib

Cox 2 selective withdrawn from market

26

Valdecoxib

Cox 2 selective withdrawn from market

27

What is the cv risk with cox 2 selective inhibitors

Cox-1 in platelets makes thromboxane which causes aggregation

Cox-2 makes prostacyclins PGI2 - which inhibits aggregation so if it's blocked there is wayyyy too much TXA2 but not enough PGI2 and you get clots.

Naproxen has the least cv risk

28

Tramadol

Not anti inflammatory
Not antipyretic
Is analgesic

Weak opioid agonist and inhibits NE and 5-HT uptake

29

Acetaminophen toxicity

Metabolized by cyp450
Results in benzoquinone imminent hat normally reacts with glutathione to form non toxic metabolites. Large does deplete the glutathione and the metabolite reacts with sulfhydryl groups in hepatic proteins to cause necrosis