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Flashcards in Antidiabetic Meds Deck (85)
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Is a contributing factor to the development of cardiovascular disease, hypertension, renal failure, blindness and stroke.

Diabetes Mallory's

1

What predisposes individuals by destroying the beta cells leading to type 1 DM

Toxins and viruses

2

An autoimmune disorder in which beta cells of the pancreas are destroyed in a genetically susceptible person

Type 1 DM

3

NO insulin is produced

Type 1 DM

4

10% of diabetes population, occurs in childhood of adolescence mostly, causes or to be thin and underweight

Type 1

5

What can lead to ketoacidosis?

Type 1

6

A metabolic disease that results from either the loss of receptor sensitivity to insulin, poor control of liver glucose output, and decreased beta cell function

Type 2 DM

7

More frequent among obese, represents 90% of diabetic population, usually in middle age, older adults.

Type 2 DM

8

Insulin resistant: decreased ability to respond to insulin, increased hepatic glucose production

Type 2 DM

9

Glucose intolerance with onset or first recognition during pregnancy.

Gestational diabetes mellitus

10

What is gestational DM diagnoses based on?

OGTT/ 100-g oral glucose tolerance test

11

What population is most affected by diabetes?

African American, American Indian, and Hispanic.

12

Level of glycosylated hemoglobin (HbA1c) to be diabetes

>/= 6.5%

13

Level of fasting plasma glucose to be diabetes

> 126mg/dL

14

2-hr plasma glucose to be diabetes

> 200 mg/dL post 75-g oral glucose challenge

15

Random plasma glucose level for diabetes

> 200 mg/dL with symptoms of diabetes (polyuria, polyphagia, and polydipsia)

16

Biguanide class

Glucophage (metformin) and glucophage XR

17

Glucophage (metformin)

2-3 times a day

18

What lowers A1c by 1-2% and decreases glucose production

Metformin (glucophage)

19

Is weight neutral or weight loss and is FIRST line of therapy after diet and exercise

Metformin

20

Has GI side effects, transient, start slow then increase, take with food to decease GI effects

Metformin

21

What should be discontinued when having general anesthesia or procedure with contrast dye?

Glucophage (don't restart for 48-72 hours until serum creatinine is documented)

22

1st generation sulfonlyureas

Orinase and diabenese

23

2nd generation sulfonlyureas

Glucotrol, glynase, diabeta

24

Tends to have fewer side effects but are more predictable and expensive

2nd generation sulfonlyureas

25

3rd generation sulfonlyureas

Amaryllis

26

Main site of action for sulfonlyureas

Pancreas (stimulates beta cell production by pancreas)

27

Side effects of sulfonlyureas

Hypoglycemia and weight gain

28

Lowers A1c by 1-2% and stimulates insulin production

Sulfonlyureas

29

Meglitinides

Prandin (repaglinide) and starlix