Antimalarial drugs Flashcards Preview

Block 6 > Antimalarial drugs > Flashcards

Flashcards in Antimalarial drugs Deck (65):
1

antimalaria symptoms

malaise
myalgia
HA
fever- periodicity
rigor

2

ABCD of malaria prevention

aware of the risk
avoid bites
chemoprophylaxis
diagnose immediantly

3

blood smear for plasmodium falciparum

smaller ring
accole
maker's spots
sickle shaped gametocytes

4

exposure for P falciparum

tropical

5

fever cycle for P falciparum

48h

6

most common cause of malaria

P falciparum

7

most chloroquine resistant

P falciparum

8

P falciparum is commonly resistant to

chloroquine
mefloquine
artemether

9

P vivax exposure

temperate
tropical

10

P vivax fever cycle

every 3rd day

11

relapsing

vivax
ovale
hypnozoites remain in liver

12

P vivax blood smear

in reticulocytes

13

P vivax and P ovale treatment

blood- anything
liver- primaquine

14

African blacks are resistant to

P vivax

15

P vivax is resistant to

chloroquine in indonesia and PNG

16

P ovale exposure

W africa

17

P ovale fever cycle

every 3rd day

18

P oval infects

reticulocytes

19

2 step treatment needed for

vivax
ovale

20

P malariae fever cycle

every 4th day

21

P malaria infects

old red blood cells

22

least common cause of malaria

P malaria

23

least virulent

P malariae

24

can infect on human primates

P lamariae
P knowlesi

25

P knowlesi exposure

SE asia

26

P knowlesi fever cycle

daily

27

chloroquine phosphate resistance

Partial- India, western indonesia
signifant- SE Asia, PNG, Afriac

28

MOA chloroquine

inhibits heme polymerase and hemazoin formation which leads to toxic heme build up in the parasite and kills it

29

MOA chloroquine resistance

pumping out of the food vacule

30

side effects of chloroquine

GI upset
itching
psoriasis exacerbation
bitter tastint

31

contraindications chloroquine

retinal disease
epilepsy

32

interactions chloroquine

intradermal rabies vaccine

33

chroloroquine prophylaxis

weekly
central america
hispaniola
middle east

34

drugs safe in pregnancy

chloroquine
mefloquine- prophylaxis
quinine- treatment

35

mefloquine resistance area

SE Asia

36

mefloquine ADR

neuropsychiatric
cardiac conduction
seizures

37

mefloquine CI

seizures
psychosis
severe depression
heart block
fine motor requirement
infants

38

mefloquine better for

prophylaxis

39

mefloquine prophylaxis schedule

weekly

40

doxycycline MOA

ribosome inhibition

41

doxycycline ADR

photosensitivity
esophagitis
yeast infections

42

doxycycline CI

kids

43

doxycycline interactions

seizure meds
pepto-bismol
iron
antacids
oral contraception

44

doxycycline prophylaxis

daily

45

chloroquine resistance treated with

doxycycline + quinine

46

atovaquone-proquanil ADR

GI upset
HA
mouth sores

47

atavaquone-proquanil CI

renal impairment
pregnancy

48

atovaquone-proquanil interactions

warfarin
rifampin
tetracycline

49

atovaquone-proquanil prophylaxis

dialy

50

#1 treatment of uncomplicated malira

atovaquone-proquanil

51

downside of atovaquone-proquanil

expensive

52

emergency self treatment

atovaquone-proquanil

53

primaquine phosphate resistance

africa

54

primaquine phosphate ADR

hemolysis in G6PD
NV
headache
methemoglobinemia

55

primaquine phosphate CI

G6PD deficiency
pregnancy
Kids

56

primaquine phosphate prophylaxis

daily

57

terminal treatment for vivax and ovale

primaquine phosphate

58

when is primaquine phosphate prophylaxis used

only if nothing else works

59

OK for seizure patients

atovaquone-proquanil

60

quinine area of resistance

SE Asia

61

quinine MOA

inhibits hemozoin biocrystallization which allows heme to build up

62

quinine ADR

cinchonism
bitter
severe hypoglycemia

63

artemether-lumefantrin MOA

reduced by iron which causes reactive oxygen radicals to be released that damage the parasite

64

artmether-lumefantrin use

treatment

65

prophylaxis drugs

chloroquine
mefloquine
doxycycline
atovaquone-proquanil
primaquine