Myeloproliferative Neoplasms Flashcards Preview

Block 6 > Myeloproliferative Neoplasms > Flashcards

Flashcards in Myeloproliferative Neoplasms Deck (40):
1

acute myeloid leukemia

myelodysplastic syndromes

2

acute myeloid leukemia

myelodysplastic syndromes

3

acute lymphoid leukemia

lymphoma

4

chronic myeloid leukemia

myeloproliferative neoplasms

5

chronic lymphoid leukemia

lymphoma

6

characteristics of acute

kids
cells can't mature

7

characteristics of chronic

adults
cells can't die

8

age for myeloproliferative neoplasms

40-60y

9

marrow cellularity

increased

10

barrow blasts

normal to increased

11

mature or immature cells

mature

12

morphology

normal
abnormal megakaryocytes

13

hematopoesis

effectiveness

14

cell lines increased

1 or more
RBC
granulocytes
megakaryocytes

15

organ enlargment

common
liver
spleen

16

signaling pathway involved

tyrosine kinase

17

chronic pahse

18

acute blast phase

>20% blasts
marrow failure

19

acute blast phase

>20% blasts
marrow failure

20

polycythemia vera

increased proliferation of erythroid precursors
JAK2 mutation
male
issues due to high viscosity blood
poikilocytosis
treatment- phelobotmy
decreased EPO
increased RBC mass in proliferative phase only
spent phase- normal/decreased RBC mass

21

chronic myeloid leukemia

myeloproliferative neoplasms

22

chronic lymphoid leukemia

lymphoma

23

characteristics of acute

kids
cells can't mature

24

characteristics of chronic

adults
cells can't die

25

age for myeloproliferative neoplasms

40-60y

26

marrow cellularity

increased

27

barrow blasts

normal to increased

28

mature or immature cells

mature

29

morphology

normal
abnormal megakaryocytes

30

hematopoesis

effectiveness

31

cell lines increased

1 or more
RBC
granulocytes
megakaryocytes

32

organ enlargment

common
liver
spleen

33

signaling pathway involved

tyrosine kinase

34

chronic pahse

35

accelerated phase

10-19% blasts

36

acute blast phase

>20% blasts
marrow failure

37

chronic myelogenous leukemia

increased proliferation of granulocytes, specifically basophils
9,22 translocation- BCR/ABL fusion protein (philadelphia chromosome)
splenomegaly
treatment- imatinab
LAP negative

38

polycythemia vera

increased proliferation of erythroid precursors
JAK2 mutation
male
issues due to high viscosity blood
treatment- phelobotmy
decreased EPO
increased RBC mass in proliferative phase only
spent phase- normal/decreased RBC mass

39

essential thrombocytopenia

increased platelets
JAK2 mutation
30y female
avoid splenectomy
doesn't progress to marrow fibrosis or acute leukemia

40

primary myelofibrosis

increased megakaryocytic
JAK2 mutation
splenomegaly- extra medullary hematopoiesis
poikilocytosis
marrow fibrosis
leukoerythroblastic smear